Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNALi, C.; Marschner, J. A.; Kusunoki, Y.; Zhang, N.; Li, X.; Deng, H.; Zhao, Z.; Watanabe-Kusunoki, K.; Zhu, Z.; Xu, Y.; Steiger, S.; Lech, M.; Susztak, K.; Schulz, C.; Anders, H.-J.
2025 Adv Sci
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Spatial Biology Using Single-Cell Mass Spectrometry Imaging and Integrated Microscopy.Potthoff, A.; Schwenzfeier, J.; Niehaus, M.; Bessler, S.; Hoffmann, E.; Soehnlein, O.; Höhndorf, J.; Dreisewerd, K.; Soltwisch, J.
2025 Nat Commun
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Inflammation in Atherosclerosis: Lessons and Therapeutic Implications |
The Dual Non-Competitive CXCR1/2 Inhibitor Ladarixin Impairs Neutrophil Extravasation without Altering Intravascular AdhesionNapoli, M.; Sitaru, S.; Budke, A.; Kammerl, A.; Querner, G.; Immler, R.; Rohwedder, I.; Seifert, S.; Ferraro, B.; Weckbach, L.; Catz, S.; Aramini, A.; Amendola, P. G.; Allegretti, M.; Bertini, R.; Pruenster, M.; Sperandio, M.
2025 Haematologica
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Posttranslational Sialylation and Its Impact on Neutrophil RecruitmentNussbaumer, K.; Marth, J. D.; Sperandio, M.
2025 J Leukoc Biol
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Development of a Circadian Immune SystemLi, X.; Rothämel, P.; Nussbaum, C.; Sperandio, M.; Scheiermann, C.
2025 Trends Immunol
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Bosutinib Mitigates Inflammation in Experimental Sepsis.Cunha, C. M. C.; Abreu, V. H. P.; Estato, V.; Soares, G. M. V.; Moraes, B. P. T.; Oliveira, G. P.; Silva, J. D.; Silva, P. L.; Immler, R.; Rocco, P. R.; Sperandio, M.; Silva, A. R.; Bozza, P. T.; Castro-Faria-Neto, H. C.; Gonçalves-de-Albuquerque, C. F.
2025 Eur J Clin Invest
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Central Trained Immunity in the Context of Bladder Cancer ImmunotherapyChronopoulos, J.; Crespo, M.; Chavakis, T.
2025 Cancer Cell
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CD45 and CD148 Are Critically Involved in Neutrophil Recruitment and Function During Inflammatory Arthritis in MiceHeming, J.-N.; Margraf, A.; Najder, K.; Germena, G.; Richter, M.; Cappenberg, A.; Henke, K.; Bardel, B.; Schemmelmann, L.; Oguama, M.; Lindental, P.; Amini, W.; Sobocik, J.; Schett, G.; Krönke, G.; Block, H.; Rossaint, J.; Soehnlein, O.; Zarbock, A.
2025 Cells
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From complexity to consensus: A roadmap for neutrophil classificationNg, L. G.; Ballesteros, I.; Cassatella, M. A.; Egeblad, M.; Fridlender, Z. G.; Gabrilovich, D.; Gao, Q.; Granot, Z.; Grieshaber-Bouyer, R.; Grimes, H. L.; Hedrick, C. C.; Hidalgo, A.; Kaplan, M. J.; Kubes, P.; Ling, G. S.; Lu, L.; Luo, H. R.; Mayadas, T. N.; Moutsopoulos, N. M.; Ng, M.; Nigrovic, P. A.; Ostuni, R.; Pittet, M. J.; Quail, D. F.; Silvestre-Roig, C.; Soehnlein, O.; Udalova, I. A.; Xue, R.; Zhang, N.; Kwok, I.
2025 Immunity
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Roadmap for Alleviating the Manifestations of Ageing in the Cardiovascular SystemLiberale, L.; Tual-Chalot, S.; Sedej, S.; Ministrini, S.; Georgiopoulos, G.; Grunewald, M.; Bäck, M.; Bochaton-Piallat, M.-L.; Boon, R. A.; Ramos, G. C.; de Winther, M. P. J.; Drosatos, K.; Evans, P. C.; Ferguson, J. F.; Forslund-Startceva, S. K.; Goettsch, C.; Giacca, M.; Haendeler, J.; Kallikourdis, M.; Ketelhuth, D. F. J.; Koenen, R. R.; Lacolley, P.; Lutgens, E.; Maffia, P.; Miwa, S.; Monaco, C.; Montecucco, F.; Norata, G. D.; Osto, E.; Richardson, G. D.; Riksen, N. P.; Soehnlein, O.; Spyridopoulos, I.; Van Linthout, S.; Vilahur, G.; Wentzel, J. J.; Andrés, V.; Badimon, L.; Benetos, A.; Binder, C. J.; Brandes, R. P.; Crea, F.; Furman, D.; Gorbunova, V.; Guzik, T. J.; Hill, J. A.; Lüscher, T. F.; Mittelbrunn, M.; Nencioni, A.; Netea, M. G.; Passos, J. F.; Stamatelopoulos, K. S.; Tavernarakis, N.; Ungvari, Z.; Wu, J. C.; Kirkland, J. L.; Camici, G. G.; Dimmeler, S.; Kroemer, G.; Abdellatif, M.; Stellos, K.
2025 Nat Rev Cardiol
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Converging Molecular Mechanisms of Nucleated Cell Death Pathways and Procoagulant Platelet FormationLi, C.; Braun, A.; Zu, J.; Gudermann, T.; Mammadova-Bach, E.; Anders, H.-J.
2025 Cells
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Interferon Regulatory Factor 8 Induces Intrinsic Functional Changes in Mature Neutrophils.Polmann, L.; Grimm, J. C.; Roth, J.; Barczyk-Kahlert, K.
2025 J Leukoc Biol
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Autophagy Hub-Protein P62 Orchestrates Oxidative, Endoplasmic Reticulum Stress, and Inflammatory Responses Post-Ischemia, Exacerbating Stroke Outcome.Quan, X.; Yang, Y.; Liu, X.; Kaltwasser, B.; Pillath-Eilers, M.; Walkenfort, B.; Voortmann, S.; Mohamud Yusuf, A.; Hagemann, N.; Wang, C.; Hasenberg, M.; Hermann, D. M.; Brockmeier, U.
2025 Redox Biology
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RhoA GAP Myo9b Regulates Β2-Integrin Activity and Neutrophil Recruitment during Murine Acute Kidney Injury.Cappenberg, A.; Oguama, M.; Richter, M.; Margraf, A.; Amini, W.; Lindental, P.; Mersmann, S.; Bardel, B.; Block, H.; Vogl, T.; Soehnlein, O.; Ley, K.; Rossaint, J.; Zarbock, A.
2025 Blood
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Csk-Mediated Src Family Kinase Regulation Dampens Neutrophil Infiltration during Pulmonary Infection.Amini, W.; Schemmelmann, L.; Heming, J.-N.; Oguama, M.; Thomas, K.; Block, H.; Lindental, P.; Bardel, B.; Margraf, A.; Soehnlein, O.; Cappenberg, A.; Zarbock, A.
2025 JCI Insight
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Alveolar Epithelial and Vascular CXCR2 Mediates Transcytosis of CXCL1 in Inflamed Lungs.Thomas, K.; Rossaint, J.; Ludwig, N.; Mersmann, S.; Kötting, N.; Grenzheuser, J.; Schemmelmann, L.; Oguama, M.; Margraf, A.; Block, H.; Henke, K.; Hellenthal, K.; Mirakaj, V.; Gerke, V.; Hansen, U.; Gäher, K.; Engelhardt, M.; Roth, J.; Eble, J.; Hub, E.; Rot, A.; Alon, R.; Zarbock, A.
2025 Nat Commun
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Gut Microbiota Deficiency Reduces Neutrophil Activation and Is Protective after Ischemic Stroke.Tuz, A. A.; Ghosh, S.; Karsch, L.; Antler, M.; Lakovic, V.; Lohmann, S.; Lehmann, A. H.; Beer, A.; Nagel, D.; Jung, M.; Hörenbaum, N.; Kaygusuz, V.; Qefalia, A.; Alshaar, B.; Amookazemi, N.; Bolsega, S.; Basic, M.; Siveke, J. T.; Heiles, S.; Grüneboom, A.; Lueong, S.; Herz, J.; Sickmann, A.; Hagemann, N.; Hasenberg, A.; Hermann, D. M.; Gunzer, M.; Singh, V.
2025 J Neuroinflammation
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Neutrophil Function in Patients With Chronic Kidney Disease: A Systematic Review and Meta-AnalysisLauxen, J. S.; Vondenhoff, S.; Junho, C. V. C.; Martin, P.; Fleig, S.; Schütt, K.; Schulze-Späte, U.; Soehnlein, O.; Prates-Roma, L.; Döring, Y.; Baaten, C. C. F. M. J.; Noels, H.
2025 Acta Physiol
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Primary Human Neutrophils and Monocytes Migrate along Endothelial Cell Boundaries to Optimize Search Efficiency under Static in Vitro Conditions.Honig, N.; Teubert, C.; Lamparter, L.; Keller, M. N.; Austermann, J.; Berger, P.; Schmitz, A.; Rasch, C.; Nüsse, H.; Klingauf, J.; Erpenbeck, L.; Roth, J.; Galic, M.
2025 Biol Open
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Broad Rim Lesions Are a New Pathological and Imaging Biomarker for Rapid Disease Progression in Multiple SclerosisKlotz, L.; Smolders, J.; Lehto, J.; Matilainen, M.; Lütje, L.; Buchholz, L.; Albrecht, S.; Walter, C.; Varghese, J.; Wiendl, H.; Nylund, M.; Thomas, C.; Gardberg, M.; van den Bosch, A. M. R.; Airas, L.; Huitinga, I.; Kuhlmann, T.
2025 Nat Med
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Effect of Long-Term Mediterranean versus Low-Fat Diet on Neutrophil Count, and Type 2 Diabetes Mellitus Remission in Patients with Coronary Heart Disease: Results from the CORDIOPREV StudyBoughanem, H.; Gutierrez-Mariscal, F. M.; Arenas-de Larriva, A. P.; Torres-Peña, J. D.; Romero-Cabrera, J. L.; Rangel-Zuñiga, O. A.; García-Fernández, H.; Podadera-Herreros, A.; Rodríguez-Cantalejo, F.; Soehnlein, O.; Macias-Gonzalez, M.; Tinahones, F. J.; Yubero Serrano, E. M.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2025 Nutr Diabetes
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Tumor Cells That Resist Neutrophil Anticancer Cytotoxicity Acquire a Prometastatic and Innate Immune Escape PhenotypeSzlachetko, J. A.; Hofmann-Vega, F.; Budeus, B.; Schröder, L.-J.; Dumitru, C. A.; Schmidt, M.; Deuss, E.; Vollmer, S.; Hanschmann, E.-M.; Busch, M.; Kehrmann, J.; Lang, S.; Dünker, N.; Hussain, T.; Brandau, S.
2025 Cell Mol Immunol
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SiglecF+ Neutrophils Link Periodontitis to Impaired Post-Myocardial Infarction RepairBoughanem, H.; Herrero-Cervera, A.; Soehnlein, O.
2025 Eur Heart J
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A Reference Database Enabling In-Depth Proteome and PTM Analysis of Mouse Immune CellsSiemes, D.; Voss, H.; Benvenuti, F.; Simoncello, F.; Kopczynski, D.; Siebels, B.; Schlüter, H.; Kollipara, L.; Sickmann, A.; Engel, D. R.; Shevchuk, O.
2025 Sci Data
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Oral Ketone Beta-Hydroxybutyrate Supplement Retards the Loss of Glomerular Filtration Rate in Alport Mice on Dual RAS/SGLT2 Blockade.Schreier, L. P.; Zhu, Z.; Kusunoki, Y.; Li, C.; Ku, J.; Klaus, M.; Anders, H.-J.
2025 Kidney360
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Podocyte A20/TNFAIP3 Controls Glomerulonephritis Severity via the Regulation of Inflammatory Responses and Effects on the Cytoskeleton.Köhler, P.; Ribeiro, A.; Honarpisheh, M.; von Rauchhaupt, E.; Lorenz, G.; Li, C.; Martin, L.; Steiger, S.; Lindenmeyer, M.; Schmaderer, C.; Anders, H.-J.; Thomasova, D.; Lech, M.
2025 Cells
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Neutrophils take their PICk to promote breast cancer. |
Harnessing Myeloid Cells in CancerPark, S.-Y.; Pylaeva, E.; Bhuria, V.; Gambardella, A. R.; Schiavoni, G.; Mougiakakos, D.; Kim, S.-H.; Jablonska, J.
2025 Molecular Cancer
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Risk beyond neutropenia: insights into neutrophil migration from newly diagnosed AML until late after allogeneic stem cell transplantationCibir, Z.; Beer, A.; Kraus, A.; Pillibeit, A.; Bludau, D.; Abdulla, H.; Neuendorff, N. R.; Sonneck, J.; Kowitz, L.; Riese, S.; Tuz, A. A.; Chen, J.; Cherneha, M.; Beelen, D. W.; Reinhardt, H. C.; Gunzer, M.; Turki, A. T.
2025 J Leukoc Biol
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Innate Immune Training of Osteoclastogenesis Promotes Inflammatory Bone Loss in MiceHaacke, N.; Wang, H.; Yan, S.; Barovic, M.; Li, X.; Nagai, K.; Botezatu, A.; Hatzioannou, A.; Gercken, B.; Trimaglio, G.; Shah, A. U.; Wang, J.; Ye, L.; Jaykar, M. T.; Rauner, M.; Wielockx, B.; Chung, K.-J.; Netea, M. G.; Kalafati, L.; Hajishengallis, G.; Chavakis, T.
2025 Dev Cell
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Distinct Inflammatory Pathways Shape Atherosclerosis in Different Vascular Beds |
Roadmap for Alleviating the Manifestations of Ageing in the Cardiovascular System.Liberale, L.; Tual-Chalot, S.; Sedej, S.; Ministrini, S.; Georgiopoulos, G.; Grunewald, M.; Bäck, M.; Bochaton-Piallat, M.-L.; Boon, R. A.; Ramos, G. C.; de Winther, M. P. J.; Drosatos, K.; Evans, P. C.; Ferguson, J. F.; Forslund-Startceva, S. K.; Goettsch, C.; Giacca, M.; Haendeler, J.; Kallikourdis, M.; Ketelhuth, D. F. J.; Koenen, R. R.; Lacolley, P.; Lutgens, E.; Maffia, P.; Miwa, S.; Monaco, C.; Montecucco, F.; Norata, G. D.; Osto, E.; Richardson, G. D.; Riksen, N. P.; Soehnlein, O.; Spyridopoulos, I.; Van Linthout, S.; Vilahur, G.; Wentzel, J. J.; Andrés, V.; Badimon, L.; Benetos, A.; Binder, C. J.; Brandes, R. P.; Crea, F.; Furman, D.; Gorbunova, V.; Guzik, T. J.; Hill, J. A.; Lüscher, T. F.; Mittelbrunn, M.; Nencioni, A.; Netea, M. G.; Passos, J. F.; Stamatelopoulos, K. S.; Tavernarakis, N.; Ungvari, Z.; Wu, J. C.; Kirkland, J. L.; Camici, G. G.; Dimmeler, S.; Kroemer, G.; Abdellatif, M.; Stellos, K.
2025 Nat Rev Cardiol
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Inhibition of Tumour Necrosis Factor Alpha by Etanercept Attenuates Shiga Toxin-Induced Brain PathologyChrist, R.; Siemes, D.; Zhao, S.; Widera, L.; Spangenberg, P.; Lill, J.; Thiebes, S.; Bottek, J.; Borgards, L.; Pinho, A. G.; Silva, N. A.; Monteiro, S.; Jorch, S. K.; Gunzer, M.; Siebels, B.; Voss, H.; Schlüter, H.; Shevchuk, O.; Chen, J.; Engel, D. R.
2025 J Neuroinflammation
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Multiomic Analysis Uncovers a Continuous Spectrum of Differentiation and Wnt-MDK-Driven Immune Evasion in HepatoblastomaMünter, D.; de Faria, F. W.; Richter, M.; Aranda-Pardos, I.; Hotfilder, M.; Walter, C.; Paga, E.; Inserte, C.; Albert, T. K.; Roy, R.; Rahman, S.; Riedel, N. C.; Müller, V.; Pascher, A.; Wiebe, K.; Schmid, I.; Vokuhl, C.; Winkler, B.; Jüttner, E.; Vieth, S.; Mücke, U.; Kluiver, T. A.; Peng, W. C.; Rossig, C.; Schlué, J.; Madadi-Sanjani, O.; Sandmann, S.; Hartmann, W.; A-Gonzalez, N.; Soehnlein, O.; Kerl, K.
2025 J Hepatol
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Trained Immunity in Chronic Inflammatory Diseases and Cancer.Hajishengallis, G.; Netea, M. G.; Chavakis, T.
2025 Nat Rev Immunol
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msiFlow: automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysisSpangenberg, P.; Bessler, S.; Widera, L.; Bottek, J.; Richter, M.; Thiebes, S.; Siemes, D.; Krauß, S. D.; Migas, L. G.; Kasarla, S. S.; Phapale, P.; Kleesiek, J.; Führer, D.; Moeller, L. C.; Heuer, H.; Van de Plas, R.; Gunzer, M.; Soehnlein, O.; Soltwisch, J.; Shevchuk, O.; Dreisewerd, K.; Engel, D. R.
2025 Nat Commun
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Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after ischemic strokeTuz, A. A.; Hoerenbaum, N.; Ulusoy, Ö.; Ahmadi, A.; Gerlach, A.; Beer, A.; Kraus, A.; Hasenberg, A.; Hagemann, N.; Hermann, D. M.; Gunzer, M.; Singh, V.
2025 Front. Immunol.
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Altered shear stress of blood flow causes plasma membrane damage in endothelial cellsRaj, N.; Pan, C.; Starke, A. M.; L. Matos, A. L.; Soehnlein, O.; Gerke, V.
2025 Blood Vessels Thromb Hemost
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β-Glucan Reprograms Neutrophils to Promote Disease Tolerance against Influenza A VirusKhan, N.; Tran, K. A.; Chevre, R.; Locher, V.; Richter, M.; Sun, S.; Sadeghi, M.; Pernet, E.; Herrero-Cervera, A.; Grant, A.; Saif, A.; Downey, J.; Kaufmann, E.; Khader, S. A.; Joubert, P.; Barreiro, L. B.; Yipp, B. G.; Soehnlein, O.; Divangahi, M.
2025 Nat Immunol
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Extrasinusoidal Macrophages Are a Distinct Subset of Immunologically Active Dural MacrophagesAmann, L.; Fell, A.; Monaco, G.; Sankowski, R.; Wu, H. Z. Q.; Jordão, M. J. C.; Borst, K.; Fliegauf, M.; Masuda, T.; Ardura-Fabregat, A.; Paterson, N.; Nent, E.; Cook, J.; Staszewski, O.; Mossad, O.; Falk, T.; Louveau, A.; Smirnov, I.; Kipnis, J.; Lämmermann, T.; Prinz, M.
2024 Sci Immunol
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Susceptibility of Melanoma Cells to Targeted Therapy Correlates with Protection by Blood NeutrophilsWendlinger, S.; Wohlfarth, J.; Siedel, C.; Kreft, S.; Kilian, T.; Junker, S.; Schmid, L.; Sinnberg, T.; Dischinger, U.; Heppt, M. V.; Wistuba-Hamprecht, K.; Meier, F.; Erpenbeck, L.; Neubert, E.; Goebeler, M.; Gesierich, A.; Schrama, D.; Kosnopfel, C.; Schilling, B.
2024 Cancers
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Ratiometric near Infrared Fluorescence Imaging of Dopamine with 1D and 2D Nanomaterials.Hill, B. F.; Mohr, J. M.; Sandvoss, I. K.; Gretz, J.; Galonska, P.; Schnitzler, L.; Erpenbeck, L.; Kruss, S.
2024 Nanoscale
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Cytosolic S100A8/A9 Promotes Ca2+ Supply at LFA-1 Adhesion Clusters during Neutrophil RecruitmentNapoli, M.; Immler, R.; Rohwedder, I.; Lupperger, V.; Pfabe, J.; Gonzalez Pisfil, M.; Yevtushenko, A.; Vogl, T.; Roth, J.; Salvermoser, M.; Dietzel, S.; Slak Rupnik, M.; Marr, C.; Walzog, B.; Sperandio, M.; Pruenster, M.
2024 Elife
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Mediterranean Diet, Neutrophil Count, and Carotid Intima-Media Thickness in Secondary Prevention: The CORDIOPREV StudyBoughanem, H.; Torres-Peña, J. D.; Arenas-de Larriva, A. P.; Romero-Cabrera, J. L.; Gómez-Luna, P.; Martín-Piedra, L.; Rodríguez-Cantalejo, F.; Tinahones, F. J.; Yubero Serrano, E. M.; Soehnlein, O.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2024 Eur Heart J
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Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence: Results From the CORDIOPREV StudyBoughanem, H.; de Larriva, A. P. A.; Camargo, A.; Torres-Peña, J. D.; Ojeda-Rodriguez, A.; Alcala-Diaz, J. F.; Romero-Cabrera, J. L.; Rangel-Zuñiga, O. A.; Rodríguez-Cantalejo, F.; Soehnlein, O.; Macias-Gonzalez, M.; Tinahones, F. J.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2024 J Clin Endocrinol Metab
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Intermittent High-Fat Diet: Atherosclerosis Progression by Neutrophil ReprogrammingHerrero-Cervera, A.; Chevre, R.; Soehnlein, O.
2024 Sig Transduct Target Ther
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Glutamine Modulates Neutrophil Recruitment and Effector Functions during Sterile InflammationHellenthal, K. E. M.; Thomas, K.; Ludwig, N.; Cappenberg, A.; Schemmelmann, L.; Tekath, T.; Margraf, A.; Mersmann, S.; Henke, K.; Rossaint, J.; Zarbock, A.; Amini, W.
2024 J Leukoc Biol
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Redistribution of PU.1 Partner Transcription Factor RUNX1 Binding Secures Cell Survival during Leukemogenesis.Bender, A.; Boydere, F.; Jayavelu, A. K.; Tibello, A.; König, T.; Aleth, H.; Meyer Zu Hörste, G.; Vogl, T.; Rosenbauer, F.
2024 EMBO J
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Novel Multiphoton Intravital Imaging Enables Real-Time Study of Helicobacter Pylori Interaction with Neutrophils and Macrophages in the Mouse StomachIshikawa-Ankerhold, H.; Busch, B.; Bader, A.; Maier-Begandt, D.; Dionisio, F.; Namineni, S.; Vladymyrov, M.; Harrison, U.; van den Heuvel, D.; Tomas, L.; Walzog, B.; Massberg, S.; Schulz, C.; Haas, R.
2024 PLoS Pathog
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Proteomic Characterization of 1,000 Human and Murine Neutrophils Freshly Isolated from Blood and Sites of Sterile Inflammation.Ghosh, S.; Tuz, A. A.; Stenzel, M.; Singh, V.; Richter, M.; Soehnlein, O.; Lange, E.; Heyer, R.; Cibir, Z.; Beer, A.; Jung, M.; Nagel, D.; Hermann, D. M.; Hasenberg, A.; Grüneboom, A.; Sickmann, A.; Gunzer, M.
2024 Mol Cell Proteomics
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Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signallingHermann, D. M.; Peruzzotti-Jametti, L.; Giebel, B.; Pluchino, S.
2024 Brain
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Arterial Specification Precedes Microvascular Restitution in the Peri-Infarct Cortex That Is Driven by Small MicrovesselsHagemann, N.; Qi, Y.; Mohamud Yusuf, A.; Li, A.; Zhang, X.; Spangenberg, P.; Squire, A.; Doeppner, T. R.; Jin, F.; Zhao, S.; Chen, J.; Mosig, A.; Gunzer, M.; Hermann, D. M.
2024 J Cereb Blood Flow Metab
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Neonatal neutrophils exhibit reduced NLRP3 inflammasome activationWackerbarth, L. M.; Seifert, S. B.; Napoli, M.; Rohwedder, I.; Vogl, T.; Scheiermann, C.; Kolben, T.; Nussbaum, C.; Pruenster, M.; Immler, R.; Sperandio, M.
2024 J Leukoc Biol
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Anti-Rubella IgG Serum Levels Predict Risk for SARS-CoV-2 Breakthrough Infections.Hollstein, M. M.; Dierks, S.; Schön, M. P.; Groß, U.; Thiele, K.; Leha, A.; Zautner, A. E.; Fischer, A.; Erpenbeck, L.; Schnelle, M.
2024 Allergy
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Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profilesPajonczyk, D.; Sternschulte, M. F.; Soehnlein, O.; Bermudez, M.; Raabe, C. A.; Rescher, U.
2024 British Journal of Pharmacology
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Inhibition of Complement Factor C5a or C5aR for Cholesterol Crystal Embolism-Related Vascular Thrombosis with Microvascular Injury and Its Consequences.Zhao, D.; Han, C.; Mammadova-Bach, E.; Watanabe-Kusunoki, K.; Honda, T. S. B.; Li, Y.; Li, C.; Li, Q.; Long, H.; Lyubenov, L.; Shi, C.; Santovito, D.; Weber, C.; Boor, P.; Droste, P.; Parikh, S.; Shapiro, J.; Chiara, L. D.; Carangelo, G.; Romagnani, P.; Klussmann, S.; Vater, A.; Anders, H.-J.
2024 Kidney Int
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DNA-Sensing Inflammasomes Cause Recurrent Atherosclerotic StrokeCao, J.; Roth, S.; Zhang, S.; Kopczak, A.; Mami, S.; Asare, Y.; Georgakis, M. K.; Messerer, D.; Horn, A.; Shemer, R.; Jacqmarcq, C.; Picot, A.; Green, J. P.; Schlegl, C.; Li, X.; Tomas, L.; Dutsch, A.; Liman, T. G.; Endres, M.; Wernsdorf, S. R.; Fürle, C.; Carofiglio, O.; Zhu, J.; Brough, D.; Veit Hornung; Dichgans, M.; Vivien, D.; Schulz, C.; Dor, Y.; Tiedt, S.; Sager, H. B.; Grosse, G. M.; Liesz, A. D.
2024 Nature
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Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relayMihlan, M.; Wissmann, S.; Gavrilov, A.; Kaltenbach, L.; Britz, M.; Franke, K.; Hummel, B.; Imle, A.; Suzuki, R.; Stecher, M.; Glaser, K. M.; Lorentz, A.; Carmeliet, P.; Yokomizo, T.; Hilgendorf, I.; Sawarkar, R.; Diz-Muñoz, A.; Buescher, J. M.; Mittler, G.; Maurer, M.; Krause, K.; Babina, M.; Erpenbeck, L.; Frank, M.; Rambold, A. S.; Lämmermann, T.
2024 Cell
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Formyl Peptide Receptor 2 (FPR2) Regulates Dendritic Cell Metabolism and Th17 Cell Differentiation during NeuroinflammationLim, J.-H.; Neuwirth, A.; Chung, K.-J.; Grossklaus, S.; Soehnlein, O.; Hajishengallis, G.; Chavakis, T.
2024 Front. Immunol
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Innate Immune Memory after Brain Injury Drives Inflammatory Cardiac DysfunctionSimats, A.; Zhang, S.; Messerer, D.; Chong, F.; Beşkardeş, S.; Chivukula, A. S.; Cao, J.; Besson-Girard, S.; Montellano, F. A.; Morbach, C.; Carofiglio, O.; Ricci, A.; Roth, S.; Llovera, G.; Singh, R.; Chen, Y.; Filser, S.; Plesnila, N.; Braun, C.; Spitzer, H.; Gokce, O.; Dichgans, M.; Heuschmann, P. U.; Hatakeyama, K.; Beltrán, E.; Clauss, S.; Bonev, B.; Schulz, C.; Liesz, A.
2024 Cell
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Functional Multi-Organelle Units Control Inflammatory Lipid Metabolism of MacrophagesZimmermann, J. A.; Lucht, K.; Stecher, M.; Badhan, C.; Glaser, K. M.; Epple, M. W.; Koch, L. R.; Deboutte, W.; Manke, T.; Ebnet, K.; Brinkmann, F.; Fehler, O.; Vogl, T.; Schuster, E.-M.; Bremser, A.; Buescher, J. M.; Rambold, A. S.
2024 Nat Cell Biol
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Neuro-Immune Crosstalk in Hematopoiesis, Inflammation, and RepairAkinyemi, D. E.; Chevre, R.; Soehnlein, O.
2024 Trends in Immunology
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Central Trained Immunity and Its Impact on Chronic Inflammatory and Autoimmune DiseasesHajishengallis, G.; Chavakis, T.
2024 Journal of Allergy and Clinical Immunology
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Neutrophils and Extracellular Traps in Crystal-Associated DiseasesMa, Q.; Steiger, S.
2024 Trends Mol Med
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Targeting Extranuclear Histones to Alleviate Acute and Chronic Inflammation.Nicolaes, G. A. F.; Soehnlein, O.
2024 Trends Pharmacol Sci
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Clonal Hematopoiesis Driven by Mutated DNMT3A Promotes Inflammatory Bone LossWang, H.; Divaris, K.; Pan, B.; Li, X.; Lim, J.-H.; Saha, G.; Barovic, M.; Giannakou, D.; Korostoff, J. M.; Bing, Y.; Sen, S.; Moss, K.; Wu, D.; Beck, J. D.; Ballantyne, C. M.; Natarajan, P.; North, K. E.; Netea, M. G.; Chavakis, T.; Hajishengallis, G.
2024 Cell
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Resident and Recruited Macrophages Differentially Contribute to Cardiac Healing after Myocardial IschemiaWeinberger, T.; Denise, M.; Joppich, M.; Fischer, M.; Garcia Rodriguez, C.; Kumaraswami, K.; Wimmler, V.; Ablinger, S.; Räuber, S.; Fang, J.; Liu, L.; Liu, W. H.; Winterhalter, J.; Lichti, J.; Thomas, L.; Esfandyari, D.; Percin, G.; Matin, S.; Hidalgo, A.; Waskow, C.; Engelhardt, S.; Todica, A.; Zimmer, R.; Pridans, C.; Gomez Perdiguero, E.; Schulz, C.
2024 eLife
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Lack of Formyl-Peptide Receptor 1 Mitigates Atherosclerosis in Hyperlipidemic Mice |
CCR3-Dependent Eosinophil Recruitment Is Regulated by Sialyltransferase ST3Gal-IV.Immler, R.; Nussbaumer, K.; Doerner, A.; El Bounkari, O.; Huber, S.; Abisch, J.; Napoli, M.; Schmidt, S.; Margraf, A.; Pruenster, M.; Rohwedder, I.; Lange-Sperandio, B.; Mall, M. A.; de Jong, R.; Ohnmacht, C.; Bernhagen, J.; Voehringer, D.; Marth, J. D.; Frommhold, D.; Sperandio, M.
2024 Proc Natl Acad Sci
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Gasdermin D drives focal Crystalline Thrombotic Microangiopathy by accelerating Immunothrombosis and NecroinflammationWatanabe-Kusunoki, K.; Li, C.; Bandeira Honda, T. S.; Zhao, D.; Kusunoki, Y.; Ku, J.; Long, H.; Klaus, M.; Han, C.; Braun, A.; Mammadova-Bach, E.; Linkermann, A.; Van Avondt, K.; Richter, M.; Soehnlein, O.; Linder, M. I.; Klein, C.; Steiger, S.; Anders, H.-J.
2024 Blood
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Stroke and Myocardial Infarction Induce Neutrophil Extracellular Trap Release Disrupting Lymphoid Organ Structure and Immunoglobulin SecretionTuz, A. A.; Ghosh, S.; Karsch, L.; Ttoouli, D.; Sata, S. P.; Ulusoy, Ö.; Kraus, A.; Hoerenbaum, N.; Wolf, J.-N.; Lohmann, S.; Zwirnlein, F.; Kaygusuz, V.; Lakovic, V.; Tummes, H.-L.; Beer, A.; Gallert, M.; Thiebes, S.; Qefalia, A.; Cibir, Z.; Antler, M.; Korste, S.; Haj Yehia, E.; Michel, L.; Rassaf, T.; Kaltwasser, B.; Abdelrahman, H.; Mohamud Yusuf, A.; Wang, C.; Yin, D.; Haeusler, L.; Lueong, S.; Richter, M.; Engel, D. R.; Stenzel, M.; Soehnlein, O.; Frank, B.; Solo-Nomenjanahary, M.; Ho-Tin-Noé, B.; Siveke, J. T.; Totzeck, M.; Hoffmann, D.; Grüneboom, A.; Hagemann, N.; Hasenberg, A.; Desilles, J.-P.; Mazighi, M.; Sickmann, A.; Chen, J.; Hermann, D. M.; Gunzer, M.; Singh, V.
2024 Nat Cardiovasc Res
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Scientific Advances in Understanding the Pathogenesis, Diagnosis, and Prevention of Urinary Tract Infection in the Past 10 YearsEngel, D. R.; Wagenlehner, F. M. E.; Shevchuk, O.
2024 Infect Dis Clin North Am
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Novel Possibilities for Targeting Neutrophils in CancerSilvestre-Roig, C.; Kalafati, L.; Chavakis, T.
2024 Sig Transduct Target Ther
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Cyclophilin A Is a Ligand for RAGE in Thrombo-InflammationSeizer, P.; von Ungern-Sternberg, S. N. I.; Haug, V.; Dicenta, V.; Rosa, A.; Butt, E.; Nöthel, M.; Rohlfing, A.-K.; Sigle, M.; Nawroth, P. P.; Nussbaum, C.; Sperandio, M.; Kusch, C.; Meub, M.; Sauer, M.; Münzer, P.; Bieber, K.; Stanger, A.; Mack, A. F.; Huber, R.; Brand, K.; Lehners, M.; Feil, R.; Poso, A.; Krutzke, K.; Schäffer, T. E.; Nieswandt, B.; Borst, O.; May, A. E.; Zernecke, A.; Gawaz, M.; Heinzmann, D.
2024 Cardiovasc Res
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Circadian Clock and HypoxiaSartor, F.; Ferrero-Bordera, B.; Haspel, J.; Sperandio, M.; Holloway, P. M.; Merrow, M.
2024 Circulation Research
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Controversies associated with the identification of the true origins of human neutrophilsSilvestre-Roig, C.; Brandau, S.
2024 Journal of Leukocyte Biology
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Potent induction of trained immunity by Saccharomyces cerevisiae β-glucansVuscan, P.; Kischkel, B.; Hatzioannou, A.; Markaki, E.; Sarlea, A.; Tintoré, M.; Cuñé, J.; Verginis, P.; de Lecea, C.; Chavakis, T.; Joosten, L. A. B.; Netea, M. G.
2024 Frontiers in Immunology
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CD38 promotes hematopoietic stem cell dormancyIbneeva, L.; Singh, S. P.; Sinha, A.; Eski, S. E.; Wehner, R.; Rupp, L.; Kovtun, I.; Pérez-Valencia, J. A.; Gerbaulet, A.; Reinhardt, S.; Wobus, M.; von Bonin, M.; Sancho, J.; Lund, F.; Dahl, A.; Schmitz, M.; Bornhäuser, M.; Chavakis, T.; Wielockx, B.; Grinenko, T.
2024 PLoS Biol
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ComplexEye: a multi-lens array microscope for high-throughput cell migration analysis |
Generation of Complex Bone Marrow Organoids from Human Induced Pluripotent Stem Cells.Frenz-Wiessner, S.; Fairley, S. D.; Buser, M.; Goek, I.; Salewskij, K.; Jonsson, G.; Illig, D.; zu Putlitz, B.; Petersheim, D.; Li, Y.; Chen, P.-H.; Kalauz, M.; Conca, R.; Sterr, M.; Geuder, J.; Mizoguchi, Y.; Megens, R. T. A.; Linder, M. I.; Kotlarz, D.; Rudelius, M.; Penninger, J. M.; Marr, C.; Klein, C.
2024 Nat Methods
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Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet MicroscopyHagemann, N.; Qi, Y.; Mohamud Yusuf, A.; Li, A.; Squire, A.; Tertel, T.; Giebel, B.; Ludewig, P.; Spangenberg, P.; Chen, J.; Mosig, A.; Gunzer, M.; Hermann, D. M.
2024 Arterioscler Thromb Vasc Biol
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Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammationArribas, V.; Onetti, Y.; Ramiro-Pareta, M.; Villacampa, P.; Beck, H.; Alberola, M.; Esteve-Codina, A.; Merkel, A.; Sperandio, M.; Martínez-Estrada, O. M.; Schmid, B.; Montanez, E.
2024 JCI Insight
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An IL-10/DEL-1 Axis Supports Granulopoiesis and Survival from Sepsis in Early LifeVergadi, E.; Kolliniati, O.; Lapi, I.; Ieronymaki, E.; Lyroni, K.; Alexaki, V. I.; Diamantaki, E.; Vaporidi, K.; Hatzidaki, E.; Papadaki, H. A.; Galanakis, E.; Hajishengallis, G.; Chavakis, T.; Tsatsanis, C.
2024 Nat Commun
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A Novel Macrolide-Del-1 Axis to Regenerate Bone in Old AgeSirisereephap, K.; Tamura, H.; Lim, J.-H.; Surboyo, M. D. C.; Isono, T.; Hiyoshi, T.; Rosenkranz, A. L.; Sato-Yamada, Y.; Domon, H.; Ikeda, A.; Hirose, T.; Sunazuka, T.; Yoshiba, N.; Okada, H.; Terao, Y.; Maeda, T.; Tabeta, K.; Chavakis, T.; Hajishengallis, G.; Maekawa, T.
2024 iScience
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Mononuclear Myeloid Cells Can Shape Neutrophils in Brain Tumors. |
Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donorsPettinella, F.; Mariotti, B.; Lattanzi, C.; Bruderek, K.; Donini, M.; Costa, S.; Marini, O.; Iannoto, G.; Gasperini, S.; Caveggion, E.; Castellucci, M.; Calzetti, F.; Bianchetto-Aguilera, F.; Gardiman, E.; Giani, M.; Dusi, S.; Cantini, M.; Vassanelli, A.; Pavone, D.; Milella, M.; Pilotto, S.; Biondani, P.; Höing, B.; Schleupner, M. C.; Hussain, T.; Hadaschik, B.; Kaspar, C.; Visco, C.; Tecchio, C.; Koenderman, L.; Bazzoni, F.; Tamassia, N.; Brandau, S.; Cassatella, M. A.; Scapini, P.
2024 CR Med
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Anti-Citrullinated Histone Monoclonal Antibody CIT-013, a Dual Action Therapeutic for Neutrophil Extracellular Trap-Associated Autoimmune Diseases.van der Linden, M.; Kumari, S.; Montizaan, D.; van Dalen, S.; Kip, A.; Foster, M.; Reinieren-Beeren, I.; Neubert, E.; Erpenbeck, L.; Waaijenberg, K.; Bruurmijn, T.; Te Poele, R.; van Zandvoort, P.; Vink, P.; Meldrum, E.; van Es, H.; Chirivi, R. G. S.
2023 MAbs
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Modulating microglia to enhance neuroplasticity for restoring brain function after strokeLiu, Z.; Hermann, D. M.; Dzyubenko, E.; Cao, G.; Cao, X.
2023 Front. Cell. Neurosci.
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Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post strokeDzyubenko, E.; Willig, K. I.; Yin, D.; Sardari, M.; Tokmak, E.; Labus, P.; Schmermund, B.; Hermann, D. M.
2023 Journal of Biomedical Science
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Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhagesYin, D.; Wang, C.; Qi, Y.; Wang, Y.-C.; Hagemann, N.; Mohamud Yusuf, A.; Dzyubenko, E.; Kaltwasser, B.; Tertel, T.; Giebel, B.; Gunzer, M.; Popa-Wagner, A.; Doeppner, T. R.; Hermann, D. M.
2023 J Neuroinflammation
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Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD MiceSchiffmann, D.; Lampkemeyer, V.; Lindner, M.; Fleck, A.-K.; Koch, K.; Eschborn, M.; Liebmann, M.; Strecker, J.-K.; Minnerup, J.; Wiendl, H.; Klotz, L.
2023 International Journal of Molecular Sciences
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrol Dial Transplant
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ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysisCibir, Z.; Hassel, J.; Sonneck, J.; Kowitz, L.; Beer, A.; Kraus, A.; Hallekamp, G.; Rosenkranz, M.; Raffelberg, P.; Olfen, S.; Smilowski, K.; Burkard, R.; Helfrich, I.; Tuz, A. A.; Singh, V.; Ghosh, S.; Sickmann, A.; Klebl, A.-K.; Eickhoff, J. E.; Klebl, B.; Seidl, K.; Chen, J.; Grabmaier, A.; Viga, R.; Gunzer, M.
2023 Nat Rev Immunol
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HPV-Associated Head and Neck Cancer Is Characterized by Distinct Profiles of CD8+ T Cells and Myeloid-Derived Suppressor CellsKansy, B. A.; Wehrs, T. P.; Bruderek, K.; Si, Y.; Ludwig, S.; Droege, F.; Hasskamp, P.; Henkel, U.; Dominas, N.; Hoffmann, T. K.; Horn, P. A.; Schuler, M.; Gauler, T. C.; Lindemann, M.; Lang, S.; Bankfalvi, A.; Brandau, S.
2023 Cancer Immunol Immunother
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Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease |
Sellhi neutrophils: a key to triumph in cancer therapyPylaeva, E.; Jablonska, J.
2023 Signal Transduction and Targeted Therapy
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E-Selectin-Mediated Rapid NLRP3 Inflammasome Activation Regulates S100A8/S100A9 Release from Neutrophils via Transient Gasdermin D Pore Formation.Pruenster, M.; Immler, R.; Roth, J.; Kuchler, T.; Bromberger, T.; Napoli, M.; Nussbaumer, K.; Rohwedder, I.; Wackerbarth, L. M.; Piantoni, C.; Hennis, K.; Fink, D.; Kallabis, S.; Schroll, T.; Masgrau-Alsina, S.; Budke, A.; Liu, W.; Vestweber, D.; Wahl-Schott, C.; Roth, J.; Meissner, F.; Moser, M.; Vogl, T.; Hornung, V.; Broz, P.; Sperandio, M.
2023 Nat Immunol
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Nuclease Activity and Protein A Release of Staphylococcus Aureus Clinical Isolates Determine the Virulence in a Murine Model of Acute Lung Infection.Ludwig, N.; Thörner-van Almsick, J.; Mersmann, S.; Bardel, B.; Niemann, S.; Chasan, A. I.; Schäfers, M.; Margraf, A.; Rossaint, J.; Kahl, B. C.; Zarbock, A.; Block, H.
2023 Front Immunol
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Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionZec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R.
2023 Front Immunol
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Externalized Histones Fuel Pulmonary Fibrosis via a Platelet-Macrophage Circuit of TGFβ1 and IL-27Riehl, D. R.; Sharma, A.; Roewe, J.; Murke, F.; Ruppert, C.; Eming, S. A.; Bopp, T.; Kleinert, H.; Radsak, M. P.; Colucci, G.; Subramaniam, S.; Reinhardt, C.; Giebel, B.; Prinz, I.; Guenther, A.; Strand, D.; Gunzer, M.; Waisman, A.; Ward, P. A.; Ruf, W.; Schäfer, K.; Bosmann, M.
2023 Proceedings of the National Academy of Sciences
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Visualization of Metabolites and Microbes at High Spatial Resolution Using MALDI Mass Spectrometry Imaging and in Situ Fluorescence Labeling.Bourceau, P.; Geier, B.; Suerdieck, V.; Bien, T.; Soltwisch, J.; Dreisewerd, K.; Liebeke, M.
2023 Nat Protoc
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S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritisvon Wulffen, M.; Luehrmann, V.; Robeck, S.; Russo, A.; Fischer-Riepe, L.; van den Bosch, M.; van Lent, P.; Loser, K.; Gabrilovich, D. I.; Hermann, S.; Roth, J.; Vogl, T.
2023 Cell Reports
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DRANquilizing neutrophil function in chronic liver disease |
Nonfunctional TGF-β/ALK1/ENG Signaling Pathway Supports Neutrophil Proangiogenic Activity in Hereditary Hemorrhagic Telangiectasia.Duerig, I.; Pylaeva, E.; Ozel, I.; Wainwright, S.; Thiel, I.; Bordbari, S.; Domnich, M.; Siakaeva, E.; Lakomek, A.; Toppe, F.; Schleupner, C.; Geisthoff, U.; Lang, S.; Droege, F.; Jablonska, J.
2023 J Leukoc Biol
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Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry ImagingBessler, S.; Soltwisch, J.; Dreisewerd, K.
2023 Anal. Chem.
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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanomaMartins Nascentes Melo, L.; Herrera-Rios, D.; Hinze, D.; Löffek, S.; Oezel, I.; Turiello, R.; Klein, J.; Leonardelli, S.; Westedt, I.-V.; Al-Matary, Y.; Egea-Rodriguez, S.; Brenzel, A.; Bau, M.; Sucker, A.; Hadaschik, E.; Wirsdörfer, F.; Hanenberg, H.; Uhlenbrock, N.; Rauh, D.; Poźniak, J.; Rambow, F.; Marine, J.-C.; Effern, M.; Glodde, N.; Schadendorf, D.; Jablonska, J.; Hölzel, M.; Helfrich, I.
2023 J Immunother Cancer
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Finerenone Added to RAS/SGLT2 Blockade for Chronic Kidney Disease in Alport Syndrome. Results of a Randomized Controlled Trial with Col4a3-/- Mice.Zhu, Z.; Rosenkranz, K. A.; Kusunoki, Y.; Li, C.; Klaus, M.; Gross, O.; Angelotti, M.-L.; Antonelli, G.; Cirillo, L.; Romagnani, P.; Bouteldja, N.; Sadr, A. V.; Bülow, R. D.; Boor, P.; Anders, H.-J.
2023 J Am Soc Nephrol
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Asymptomatic Hyperuricaemia in Chronic Kidney Disease: Mechanisms and Clinical Implications. |
The Five Types of Glomerulonephritis Classified by Pathogenesis, Activity, and Chronicity (GN-AC)Romagnani, P.; Kitching, A. R.; Leung, N.; Anders, H.-J.
2023 Nephrol Dial Transplant
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Inflammaging aggravates stroke pathology |
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
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The Roles of Toll-like Receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for Monocyte Activation by the DAMP S100A8/S100A9Möller, A.; Jauch-Speer, S.-L.; Gandhi, S.; Vogl, T.; Roth, J.; Fehler, O.
2023 Front Immunol
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S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of LeukocytesWolf, M.; Joseph, R.; Austermann, J.; Scharrnbeck-Davis, C.; Hermann, S.; Roth, J.; Vogl, T.
2023 Biomedicines
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Macrophage Function in Adipose Tissue Homeostasis and Metabolic InflammationChavakis, T.; Alexaki, V. I.; Ferrante, A. W.
2023 Nat Immunol
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Rapid and Fully Automated Blood Vasculature Analysis in 3D Light-Sheet Image Volumes of Different OrgansSpangenberg, P.; Hagemann, N.; Squire, A.; Förster, N.; Krauß, S. D.; Qi, Y.; Yusuf, A. M.; Wang, J.; Grüneboom, A.; Kowitz, L.; Korste, S.; Totzeck, M.; Cibir, Z.; Tuz, A. A.; Singh, V.; Siemes, D.; Struensee, L.; Engel, D. R.; Ludewig, P.; Nascentes Melo, L. M.; Helfrich, I.; Chen, J.; Gunzer, M.; Hermann, D. M.; Mosig, A.
2023 Cell Reports Methods
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The Angiopoietin Receptor Tie2 Is Atheroprotective in Arterial EndotheliumAnisimov, A.; Fang, S.; Hemanthakumar, K. A.; Örd, T.; van Avondt, K.; Chevre, R.; Toropainen, A.; Singha, P.; Gilani, H.; Nguyen, S. D.; Karaman, S.; Korhonen, E. A.; Adams, R. H.; Augustin, H. G.; Öörni, K.; Soehnlein, O.; Kaikkonen, M. U.; Alitalo, K.
2023 Nat Cardiovasc Res
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A20 and the Noncanonical NF-κB Pathway Are Key Regulators of Neutrophil Recruitment during Fetal OntogenyRohwedder, I.; Wackerbarth, L. M.; Heinig, K.; Ballweg, A.; Altstätter, J.; Ripphahn, M.; Nussbaum, C.; Salvermoser, M.; Bierschenk, S.; Straub, T.; Gunzer, M.; Schmidt-Supprian, M.; Kolben, T.; Schulz, C.; Ma, A.; Walzog, B.; Heinig, M.; Sperandio, M.
2023 JCI Insight
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Analyzing Mitochondrial Respiration of Human Induced Pluripotent Stem Cell-Derived Myeloid Progenitors Using Seahorse TechnologyFan, Y.; Mizoguchi, Y.; Tatematsu, M.; Linder, M. I.; Frenz, S.; Choi, J.; Klein, C.
2023 STAR Protoc
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Complex Regulation of Alarmins S100A8/A9 and Secretion via Gasdermin-D Pores Exacerbates Autoinflammation in Familial Mediterranean FeverJorch, S. K.; McNally, A.; Berger, P.; Wolf, J.; Kaiser, K.; Chetrusca Covash, A.; Robeck, S.; Pastau, I.; Fehler, O.; Jauch-Speer, S.-L.; Hermann, S.; Schäfers, M.; Van Gorp, H.; Kanneganti, A.; Dehoorne, J.; Haerynck, F.; Penco, F.; Gattorno, M.; Chae, J. J.; Kubes, P.; Lamkanfi, M.; Wullaert, A.; Sperandio, M.; Vogl, T.; Roth, J.; Austermann, J.
2023 J Allergy Clin Immunol
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Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
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Targeting Neutrophil Extracellular Traps (NETs) Ameliorates Inflammation in Murine Psoriasiform DermatitisHollstein, M. M.; Manzke, V.; Scheidmann, S. E. F.; Schrenker, S.; Schaffrinski, M.; Neubert, E.; Kramer, D.; Raker, V. K.; Schön, M. P.; Erpenbeck, L.
2023 J Dermatol Sci
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Glycolytic Side Pathways Regulating Macrophage Inflammatory Phenotypes and FunctionsDionísio, F.; Tomas, L.; Schulz, C.
2023 Am J Physiol Cell Physiol
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Non-Invasive Mapping of Systemic Neutrophil Dynamics upon Cardiovascular InjuryBouvain, P.; Ding, Z.; Kadir, S.; Kleimann, P.; Kluge, N.; Tiren, Z.-B.; Steckel, B.; Flocke, V.; Zalfen, R.; Petzsch, P.; Wachtmeister, T.; John, G.; Subramaniam, N.; Krämer, W.; Strasdeit, T.; Mehrabipour, M.; Moll, J. M.; Schubert, R.; Ahmadian, M. R.; Bönner, F.; Boeken, U.; Westenfeld, R.; Engel, D. R.; Kelm, M.; Schrader, J.; Köhrer, K.; Grandoch, M.; Temme, S.; Flögel, U.
2023 Nature Cardiovascular Research
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Hijacking CD177 for whole-body visualization of neutrophil dynamics |
Longitudinal in vivo monitoring of atheroprogression in hypercholesterolemic mice using photoacoustic imagingFerraro, B.; Giustetto, P.; Schengel, O.; Weckbach, L.; Maegdefessel, L.; Soehnlein, O.
2023 Thromb Haemost
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Human Genetic Defects in SRP19 and SRPRA Cause Severe Congenital Neutropenia with Distinctive Proteome ChangesLinder, M. I.; Mizoguchi, Y.; Hesse, S.; Csaba, G.; Tatematsu, M.; Łyszkiewicz, M.; Zietara, N.; Jeske, T.; Hastreiter, M.; Rohlfs, M.; Liu, Y.; Grabowski, P.; Ahomaa, K.; Maier-Begandt, D.; Schwestka, M.; Pazhakh, V.; Isiaku, A.; Briones Miranda, B.; Blombery, P.; Saito, M. K.; Rusha, E.; Alizadeh, Z.; Pourpak, Z.; Kobayashi, M.; Rezaei, N.; Unal, E.; Hauck, F.; Drukker, M.; Walzog, B.; Rappsilber, J.; Zimmer, R.; Lieschke, G. J.; Klein, C.
2023 Blood
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During Early Stages of Cancer, Neutrophils Initiate Anti-Tumor Immune Responses in Tumor-Draining Lymph NodesPylaeva, E.; Korschunow, G.; Spyra, I.; Bordbari, S.; Siakaeva, E.; Ozel, I.; Domnich, M.; Squire, A.; Hasenberg, A.; Thangavelu, K.; Hussain, T.; Goetz, M.; Lang, K. S.; Gunzer, M.; Hansen, W.; Buer, J.; Bankfalvi, A.; Lang, S.; Jablonska, J.
2022 Cell Reports
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Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammationMauersberger, C.; Sager, H. B.; Wobst, J.; Dang, T. A.; Lambrecht, L.; Koplev, S.; Stroth, M.; Bettaga, N.; Schlossmann, J.; Wunder, F.; Friebe, A.; Björkegren, J. L. M.; Dietz, L.; Maas, S. L.; van der Vorst, E. P. C.; Sandner, P.; Soehnlein, O.; Schunkert, H.; Kessler, T.
2022 Nature Cardiovascular Research
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N1 versus N2 and PMN-MDSC: A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncologyAntuamwine, B. B.; Bosnjakovic, R.; Hofmann-Vega, F.; Wang, X.; Theodosiou, T.; Iliopoulos, I.; Brandau, S.
2022 Immunological Reviews
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Expansion microscopy of neutrophil nuclear structure and extracellular trapsHolsapple, J. S.; Schnitzler, L.; Rusch, L.; Baldeweg, T. H.; Neubert, E.; Kruss, S.; Erpenbeck, L.
2022 Biophys Rep
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Role of S100A8/A9 in Platelet–Neutrophil Complex Formation during Acute InflammationRevenstorff, J.; Ludwig, N.; Hilger, A.; Mersmann, S.; Lehmann, M.; Grenzheuser, J. C.; Kardell, M.; Bone, J.; Kötting, N. M.; Marx, N. C.; Roth, J.; Vogl, T.; Rossaint, J.
2022 Cells
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Pathological neutrophil migration predicts adverse outcomes in hospitalized patients with liver cirrhosisLanger, M.-M.; Sichelschmidt, S.; Bauschen, A.; Bornemann, L.; Guckenbiehl, S.; Gunzer, M.; Lange, C. M.
2022 Liver International
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Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recoveryTuz, A. A.; Hasenberg, A.; Hermann, D. M.; Gunzer, M.; Singh, V.
2022 Frontiers in Immunology
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Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on MonocytesRusso, A.; Schürmann, H.; Brandt, M.; Scholz, K.; Matos, A. L. L.; Grill, D.; Revenstorff, J.; Rembrink, M.; von Wulffen, M.; Fischer-Riepe, L.; Hanley, P. J.; Häcker, H.; Prünster, M.; Sánchez-Madrid, F.; Hermann, S.; Klotz, L.; Gerke, V.; Betz, T.; Vogl, T.; Roth, J.
2022 Advanced Science
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Neutrophils in aging and aging-related pathologiesVan Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O.
2022 Immunol Rev
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Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular diseasePetzold, T.; Zhang, Z.; Ballesteros, I.; Saleh, I.; Polzin, A.; Thienel, M.; Liu, L.; Ul Ain, Q.; Ehreiser, V.; Weber, C.; Kilani, B.; Mertsch, P.; Götschke, J.; Cremer, S.; Fu, W.; Lorenz, M.; Ishikawa-Ankerhold, H.; Raatz, E.; El-Nemr, S.; Görlach, A.; Marhuenda, E.; Stark, K.; Pircher, J.; Stegner, D.; Gieger, C.; Schmidt-Supprian, M.; Gaertner, F.; Almendros, I.; Kelm, M.; Schulz, C.; Hidalgo, A.; Massberg, S.
2022 Immunity
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The Role of Neutrophils in Trained ImmunityKalafati, L.; Hatzioannou, A.; Hajishengallis, G.; Chavakis, T.
2022 Immunol Rev
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Glutamine Prevents Acute Kidney Injury by Modulating Oxidative Stress and Apoptosis in Tubular Epithelial CellsThomas, K.; Zondler, L.; Ludwig, N.; Kardell, M.; Lüneburg, C.; Henke, K.; Mersmann, S.; Margraf, A.; Spieker, T.; Tekath, T.; Velic, A.; Holtmeier, R.; Hermann, J.; Jankowski, V.; Meersch, M.; Vestweber, D.; Westphal, M.; Roth, J.; Schäfers, M. A.; Kellum, J. A.; Lowell, C. A.; Rossaint, J.; Zarbock, A.
2022 JCI Insight
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PMN-MDSC in newborns: Regulation of the regulators |
Neutrophil circadian rhythm is associated with different outcomes of acute kidney injury due to cholesterol crystal embolismShi, C.; Zhao, D.; Lyubenov, L.; Motrapu, M.; Li, N.; Steiger, S.; Mammadova-Bach, E.; Yang, L.; Liu, D.; Anders, H.-J.
2022 Front Cardiovasc Med
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AIMing 2 treat atherosclerosis |
Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formationSohrabi, Y.; Reinecke, H.; Soehnlein, O.
2022 Signal Transduct Target Ther
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Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation |
Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human NeutrophilsSchirrmann, R.; Erkelenz, M.; Lamers, K.; Sritharan, O.; Nachev, M.; Sures, B.; Schlücker, S.; Brandau, S.
2022 ACS Nano
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