Dissecting the anti-tumour effects of trained neutrophils
Neutrophils exert both pro- and anti-tumour activities. A frequent scenario in cancer is that tumours hijack granulopoiesis resulting in a tumour-promoting neutrophil phenotype. Trained innate immunity indicates that some stimuli can induce, via epigenetic rewiring, long-term functional changes in myeloid cells and their progenitors, leading to an increased reaction upon exposure to a secondary challenge. Here we will dissect how innate immune training of granulopoiesis and neutrophils promotes anti-tumour activity. Our work will establish innate immune training of neutrophils as a novel adjuvant tumour immunotherapy.
Team
Publications
Novel Possibilities for Targeting Neutrophils in CancerSilvestre-Roig, C.; Kalafati, L.; Chavakis, T.
2024 Sig Transduct Target Ther
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Potent induction of trained immunity by Saccharomyces cerevisiae β-glucansVuscan, P.; Kischkel, B.; Hatzioannou, A.; Markaki, E.; Sarlea, A.; Tintoré, M.; Cuñé, J.; Verginis, P.; de Lecea, C.; Chavakis, T.; Joosten, L. A. B.; Netea, M. G.
2024 Frontiers in Immunology
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CD38 promotes hematopoietic stem cell dormancyIbneeva, L.; Singh, S. P.; Sinha, A.; Eski, S. E.; Wehner, R.; Rupp, L.; Kovtun, I.; Pérez-Valencia, J. A.; Gerbaulet, A.; Reinhardt, S.; Wobus, M.; von Bonin, M.; Sancho, J.; Lund, F.; Dahl, A.; Schmitz, M.; Bornhäuser, M.; Chavakis, T.; Wielockx, B.; Grinenko, T.
2024 PLoS Biol
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An IL-10/DEL-1 Axis Supports Granulopoiesis and Survival from Sepsis in Early LifeVergadi, E.; Kolliniati, O.; Lapi, I.; Ieronymaki, E.; Lyroni, K.; Alexaki, V. I.; Diamantaki, E.; Vaporidi, K.; Hatzidaki, E.; Papadaki, H. A.; Galanakis, E.; Hajishengallis, G.; Chavakis, T.; Tsatsanis, C.
2024 Nat Commun
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A Novel Macrolide-Del-1 Axis to Regenerate Bone in Old AgeSirisereephap, K.; Tamura, H.; Lim, J.-H.; Surboyo, M. D. C.; Isono, T.; Hiyoshi, T.; Rosenkranz, A. L.; Sato-Yamada, Y.; Domon, H.; Ikeda, A.; Hirose, T.; Sunazuka, T.; Yoshiba, N.; Okada, H.; Terao, Y.; Maeda, T.; Tabeta, K.; Chavakis, T.; Hajishengallis, G.; Maekawa, T.
2024 iScience
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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Macrophage Function in Adipose Tissue Homeostasis and Metabolic InflammationChavakis, T.; Alexaki, V. I.; Ferrante, A. W.
2023 Nat Immunol
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The Role of Neutrophils in Trained ImmunityKalafati, L.; Hatzioannou, A.; Hajishengallis, G.; Chavakis, T.
2022 Immunological Reviews
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Mechanisms and Therapeutic Modulation of Neutrophil-Mediated InflammationHajishengallis, G.; Chavakis, T.
2022 Journal of Dental Research
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