Project Area B: Intracellular regulation

Neutrophils exert both pro- and anti-tumour activities. A frequent scenario in cancer is that tumours hijack granulopoiesis resulting in a tumour-promoting neutrophil phenotype. Trained innate immunity indicates that some stimuli can induce, via epigenetic rewiring, long-term functional changes in myeloid cells and their progenitors, leading to an increased reaction upon exposure to a secondary challenge. Here we will dissect how innate immune training of granulopoiesis and neutrophils promotes anti-tumour activity. Our work will establish innate immune training of neutrophils as a novel adjuvant tumour immunotherapy.