Dissecting the anti-tumour effects of trained neutrophils

Neutrophils exert both pro- and anti-tumour activities. A frequent scenario in cancer is that tumours hijack granulopoiesis resulting in a tumour-promoting neutrophil phenotype. Trained innate immunity indicates that some stimuli can induce, via epigenetic rewiring, long-term functional changes in myeloid cells and their progenitors, leading to an increased reaction upon exposure to a secondary challenge. Here we will dissect how innate immune training of granulopoiesis and neutrophils promotes anti-tumour activity. Our work will establish innate immune training of neutrophils as a novel adjuvant tumour immunotherapy.
Team
Publications
Macrophage Function in Adipose Tissue Homeostasis and Metabolic InflammationChavakis, T.; Alexaki, V. I.; Ferrante, A. W.
2023 Nat Immunol
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The Role of Neutrophils in Trained ImmunityKalafati, L.; Hatzioannou, A.; Hajishengallis, G.; Chavakis, T.
2022 Immunological Reviews
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Mechanisms and Therapeutic Modulation of Neutrophil-Mediated InflammationHajishengallis, G.; Chavakis, T.
2022 Journal of Dental Research
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