Pan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.

2023 Circulation

Lifestyle and nutritional habits represent critical triggers for immune-metabolic disorders, including nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.1 Time-restricted feeding (TRF) has been shown to improve immune-metabolic functions by sharpening their diurnal rhythmicity.1,2 During chronic high-fat diet intake, TRF mitigates body weight gain, improves metabolic fitness, and inhibits NAFLD.1 However, data regarding TRF and atherosclerosis development are surprisingly scarce. Here, we report that TRF dramatically accelerates atherogenesis by enhancing the diurnal recruitment of myeloid leukocytes to atheroprone arteries.