Visualizing neutrophils in context
Context-dependent neutrophil production, fate, migration and function is a central scientific question of this collaborative initiative. Using state-of-the-art imaging approaches, such as MALDI MSI and multiplex microscopy, in combination with innovative bioinformatics algorithms for the registration and analysis of the imaging data sets, we will here provide a powerful platform for all partner sites to visualize and analyse context-dependent neutrophil biology.
Team
Publications
Mediterranean Diet, Neutrophil Count, and Carotid Intima-Media Thickness in Secondary Prevention: The CORDIOPREV StudyBoughanem, H.; Torres-Peña, J. D.; Arenas-de Larriva, A. P.; Romero-Cabrera, J. L.; Gómez-Luna, P.; Martín-Piedra, L.; Rodríguez-Cantalejo, F.; Tinahones, F. J.; Yubero Serrano, E. M.; Soehnlein, O.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2024 Eur Heart J
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Formyl Peptide Receptor 2 (FPR2) Regulates Dendritic Cell Metabolism and Th17 Cell Differentiation during NeuroinflammationLim, J.-H.; Neuwirth, A.; Chung, K.-J.; Grossklaus, S.; Soehnlein, O.; Hajishengallis, G.; Chavakis, T.
2024 Front. Immunol
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Neuro-Immune Crosstalk in Hematopoiesis, Inflammation, and RepairAkinyemi, D. E.; Chevre, R.; Soehnlein, O.
2024 Trends in Immunology
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Targeting Extranuclear Histones to Alleviate Acute and Chronic Inflammation.Nicolaes, G. A. F.; Soehnlein, O.
2024 Trends Pharmacol Sci
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Lack of Formyl-Peptide Receptor 1 Mitigates Atherosclerosis in Hyperlipidemic Mice |
Gasdermin D drives focal Crystalline Thrombotic Microangiopathy by accelerating Immunothrombosis and NecroinflammationWatanabe-Kusunoki, K.; Li, C.; Bandeira Honda, T. S.; Zhao, D.; Kusunoki, Y.; Ku, J.; Long, H.; Klaus, M.; Han, C.; Braun, A.; Mammadova-Bach, E.; Linkermann, A.; Van Avondt, K.; Richter, M.; Soehnlein, O.; Linder, M. I.; Klein, C.; Steiger, S.; Anders, H.-J.
2024 Blood
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Stroke and Myocardial Infarction Induce Neutrophil Extracellular Trap Release Disrupting Lymphoid Organ Structure and Immunoglobulin SecretionTuz, A. A.; Ghosh, S.; Karsch, L.; Ttoouli, D.; Sata, S. P.; Ulusoy, Ö.; Kraus, A.; Hoerenbaum, N.; Wolf, J.-N.; Lohmann, S.; Zwirnlein, F.; Kaygusuz, V.; Lakovic, V.; Tummes, H.-L.; Beer, A.; Gallert, M.; Thiebes, S.; Qefalia, A.; Cibir, Z.; Antler, M.; Korste, S.; Haj Yehia, E.; Michel, L.; Rassaf, T.; Kaltwasser, B.; Abdelrahman, H.; Mohamud Yusuf, A.; Wang, C.; Yin, D.; Haeusler, L.; Lueong, S.; Richter, M.; Engel, D. R.; Stenzel, M.; Soehnlein, O.; Frank, B.; Solo-Nomenjanahary, M.; Ho-Tin-Noé, B.; Siveke, J. T.; Totzeck, M.; Hoffmann, D.; Grüneboom, A.; Hagemann, N.; Hasenberg, A.; Desilles, J.-P.; Mazighi, M.; Sickmann, A.; Chen, J.; Hermann, D. M.; Gunzer, M.; Singh, V.
2024 Nat Cardiovasc Res
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Scientific Advances in Understanding the Pathogenesis, Diagnosis, and Prevention of Urinary Tract Infection in the Past 10 YearsEngel, D. R.; Wagenlehner, F. M. E.; Shevchuk, O.
2024 Infect Dis Clin North Am
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Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease |
Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionZec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R.
2023 Front. Immunol.
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Visualization of Metabolites and Microbes at High Spatial Resolution Using MALDI Mass Spectrometry Imaging and in Situ Fluorescence Labeling.Bourceau, P.; Geier, B.; Suerdieck, V.; Bien, T.; Soltwisch, J.; Dreisewerd, K.; Liebeke, M.
2023 Nat Protoc
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DRANquilizing neutrophil function in chronic liver diseaseGroba, S. R., & Soehnlein, O.
2023 Journal of Hepatology.
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Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry ImagingBessler, S.; Soltwisch, J.; Dreisewerd, K.
2023 Anal. Chem.
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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
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Rapid and Fully Automated Blood Vasculature Analysis in 3D Light-Sheet Image Volumes of Different OrgansSpangenberg, P.; Hagemann, N.; Squire, A.; Förster, N.; Krauß, S. D.; Qi, Y.; Yusuf, A. M.; Wang, J.; Grüneboom, A.; Kowitz, L.; Korste, S.; Totzeck, M.; Cibir, Z.; Tuz, A. A.; Singh, V.; Siemes, D.; Struensee, L.; Engel, D. R.; Ludewig, P.; Nascentes Melo, L. M.; Helfrich, I.; Chen, J.; Gunzer, M.; Hermann, D. M.; Mosig, A.
2023 Cell Reports Methods
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The Angiopoietin Receptor Tie2 Is Atheroprotective in Arterial EndotheliumAnisimov, A.; Fang, S.; Hemanthakumar, K. A.; Örd, T.; van Avondt, K.; Chevre, R.; Toropainen, A.; Singha, P.; Gilani, H.; Nguyen, S. D.; Karaman, S.; Korhonen, E. A.; Adams, R. H.; Augustin, H. G.; Öörni, K.; Soehnlein, O.; Kaikkonen, M. U.; Alitalo, K. 2023, 1–15.
2023 Nat Cardiovasc Res
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Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
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Longitudinal in vivo monitoring of atheroprogression in hypercholesterolemic mice using photoacoustic imagingFerraro, B.; Giustetto, P.; Schengel, O.; Weckbach, L.; Maegdefessel, L.; Soehnlein, O.
2023 Thromb Haemost
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Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammationMauersberger, C.; Sager, H. B.; Wobst, J.; Dang, T. A.; Lambrecht, L.; Koplev, S.; Stroth, M.; Bettaga, N.; Schlossmann, J.; Wunder, F.; Friebe, A.; Björkegren, J. L. M.; Dietz, L.; Maas, S. L.; van der Vorst, E. P. C.; Sandner, P.; Soehnlein, O.; Schunkert, H.; Kessler, T.
2022 Nature Cardiovascular Research
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Neutrophils in aging and aging-related pathologiesVan Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O.
2022 Immunological Reviews
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AIMing 2 treat atherosclerosisSoehnlein, O.; Tall, A. R.
2022 Nature Reviews Cardiology
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Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formationSohrabi, Y.; Reinecke, H.; Soehnlein, O.
2022 Signal Transduction and Targeted Therapy
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