Macrophage regulation of neutrophil phenotype and function
Neutrophils are potent effector cells and therefore require precise regulation. Within organs, they quickly adopt tissue-dependent properties to serve specific physiological needs. Because neutrophils and macrophages frequently interact, we hypothesize that tissue-resident macrophages modulate neutrophil properties. Here, we will determine the impact of tissue macrophages on neutrophil phenotypes and functions, and characterize the potential role of the developmental origin of macrophages therein. Further, we will analyse the importance of macrophages for shaping neutrophil properties in a model of cardiac injury.
Team
Publications
Novel Multiphoton Intravital Imaging Enables Real-Time Study of Helicobacter Pylori Interaction with Neutrophils and Macrophages in the Mouse StomachIshikawa-Ankerhold, H.; Busch, B.; Bader, A.; Maier-Begandt, D.; Dionisio, F.; Namineni, S.; Vladymyrov, M.; Harrison, U.; van den Heuvel, D.; Tomas, L.; Walzog, B.; Massberg, S.; Schulz, C.; Haas, R.
2024 PLoS Pathog
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DNA-Sensing Inflammasomes Cause Recurrent Atherosclerotic StrokeCao, J.; Roth, S.; Zhang, S.; Kopczak, A.; Mami, S.; Asare, Y.; Georgakis, M. K.; Messerer, D.; Horn, A.; Shemer, R.; Jacqmarcq, C.; Picot, A.; Green, J. P.; Schlegl, C.; Li, X.; Tomas, L.; Dutsch, A.; Liman, T. G.; Endres, M.; Wernsdorf, S. R.; Fürle, C.; Carofiglio, O.; Zhu, J.; Brough, D.; Veit Hornung; Dichgans, M.; Vivien, D.; Schulz, C.; Dor, Y.; Tiedt, S.; Sager, H. B.; Grosse, G. M.; Liesz, A. D.
2024 Nature
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Innate Immune Memory after Brain Injury Drives Inflammatory Cardiac DysfunctionSimats, A.; Zhang, S.; Messerer, D.; Chong, F.; Beşkardeş, S.; Chivukula, A. S.; Cao, J.; Besson-Girard, S.; Montellano, F. A.; Morbach, C.; Carofiglio, O.; Ricci, A.; Roth, S.; Llovera, G.; Singh, R.; Chen, Y.; Filser, S.; Plesnila, N.; Braun, C.; Spitzer, H.; Gokce, O.; Dichgans, M.; Heuschmann, P. U.; Hatakeyama, K.; Beltrán, E.; Clauss, S.; Bonev, B.; Schulz, C.; Liesz, A.
2024 Cell
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Resident and Recruited Macrophages Differentially Contribute to Cardiac Healing after Myocardial IschemiaWeinberger, T.; Denise, M.; Joppich, M.; Fischer, M.; Garcia Rodriguez, C.; Kumaraswami, K.; Wimmler, V.; Ablinger, S.; Räuber, S.; Fang, J.; Liu, L.; Liu, W. H.; Winterhalter, J.; Lichti, J.; Thomas, L.; Esfandyari, D.; Percin, G.; Matin, S.; Hidalgo, A.; Waskow, C.; Engelhardt, S.; Todica, A.; Zimmer, R.; Pridans, C.; Gomez Perdiguero, E.; Schulz, C.
2024 eLife
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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Inflammaging aggravates stroke pathology |
A20 and the Noncanonical NF-κB Pathway Are Key Regulators of Neutrophil Recruitment during Fetal OntogenyRohwedder, I.; Wackerbarth, L. M.; Heinig, K.; Ballweg, A.; Altstätter, J.; Ripphahn, M.; Nussbaum, C.; Salvermoser, M.; Bierschenk, S.; Straub, T.; Gunzer, M.; Schmidt-Supprian, M.; Kolben, T.; Schulz, C.; Ma, A.; Walzog, B.; Heinig, M.; Sperandio, M.
2023 JCI Insight
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Glycolytic Side Pathways Regulating Macrophage Inflammatory Phenotypes and FunctionsDionísio, F.; Tomas, L.; Schulz, C.
2023 Am J Physiol Cell Physiol
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Neutrophils in aging and aging-related pathologiesVan Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O.
2022 Immunological Reviews
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Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular diseasePetzold, T.; Zhang, Z.; Ballesteros, I.; Saleh, I.; Polzin, A.; Thienel, M.; Liu, L.; Ul Ain, Q.; Ehreiser, V.; Weber, C.; Kilani, B.; Mertsch, P.; Götschke, J.; Cremer, S.; Fu, W.; Lorenz, M.; Ishikawa-Ankerhold, H.; Raatz, E.; El-Nemr, S.; Görlach, A.; Marhuenda, E.; Stark, K.; Pircher, J.; Stegner, D.; Gieger, C.; Schmidt-Supprian, M.; Gaertner, F.; Almendros, I.; Kelm, M.; Schulz, C.; Hidalgo, A.; Massberg, S.
2022 Immunity
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