A6

Macrophage regulation of neutrophil phenotype and function

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Neutrophils are potent effector cells and therefore require precise regulation. Within organs, they quickly adopt tissue-dependent properties to serve specific physiological needs. Because neutrophils and macrophages frequently interact, we hypothesize that tissue-resident macrophages modulate neutrophil properties. Here, we will determine the impact of tissue macrophages on neutrophil phenotypes and functions, and characterize the potential role of the developmental origin of macrophages therein. Further, we will analyse the importance of macrophages for shaping neutrophil properties in a model of cardiac injury.

Team

Publications

Resident and Recruited Macrophages Differentially Contribute to Cardiac Healing after Myocardial Ischemia

Weinberger, T.; Denise, M.; Joppich, M.; Fischer, M.; Garcia Rodriguez, C.; Kumaraswami, K.; Wimmler, V.; Ablinger, S.; Räuber, S.; Fang, J.; Liu, L.; Liu, W. H.; Winterhalter, J.; Lichti, J.; Thomas, L.; Esfandyari, D.; Percin, G.; Matin, S.; Hidalgo, A.; Waskow, C.; Engelhardt, S.; Todica, A.; Zimmer, R.; Pridans, C.; Gomez Perdiguero, E.; Schulz, C.

2024 eLife

Neutrophils - Biology and Diversity

Maier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.

2023 Nephrology Dialysis Transplantation

Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

Petzold, T.; Zhang, Z.; Ballesteros, I.; Saleh, I.; Polzin, A.; Thienel, M.; Liu, L.; Ul Ain, Q.; Ehreiser, V.; Weber, C.; Kilani, B.; Mertsch, P.; Götschke, J.; Cremer, S.; Fu, W.; Lorenz, M.; Ishikawa-Ankerhold, H.; Raatz, E.; El-Nemr, S.; Görlach, A.; Marhuenda, E.; Stark, K.; Pircher, J.; Stegner, D.; Gieger, C.; Schmidt-Supprian, M.; Gaertner, F.; Almendros, I.; Kelm, M.; Schulz, C.; Hidalgo, A.; Massberg, S.

2022 Immunity