Impact of type I interferons on tumour-dependent granulopoiesis and neutrophil tumourigenicity


The aim of this proposal is to unravel the role of IFN receptor (IFNAR1) in the development of tumour-associated neutrophils. As lack of IFNAR1 leads to pro-tumour activity of neutrophils and as IFNAR1 expression is significantly downregulated in the tumour microenvironment, we hypothesize that the tumour actively disturbs IFNAR1 signalling to support the development of pro-tumour neutrophils. Bearing this in mind, we aim to identify the molecular mechanisms involved in the development of neutrophils in IFNAR1 deficiency, thus potentially identifying novel therapeutic targets that allow to reverse the pro-tumour bias of neutrophils.



Neutrophils - Biology and Diversity

Maier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.

2023 Nephrology Dialysis Transplantation

Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection

Zec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R.

2023 Front. Immunol.

Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma

Martins Nascentes Melo, L.; Herrera-Rios, D.; Hinze, D.; Löffek, S.; Oezel, I.; Turiello, R.; Klein, J.; Leonardelli, S.; Westedt, I.-V.; Al-Matary, Y.; Egea-Rodriguez, S.; Brenzel, A.; Bau, M.; Sucker, A.; Hadaschik, E.; Wirsdörfer, F.; Hanenberg, H.; Uhlenbrock, N.; Rauh, D.; Poźniak, J.; Rambow, F.; Marine, J.-C.; Effern, M.; Glodde, N.; Schadendorf, D.; Jablonska, J.; Hölzel, M.; Helfrich, I.

2023 J Immunother Cancer