Regulatory role of type I interferon signalling in skewing anti-tumoural granulopoiesis
Current cancer immunotherapies tend to neglect the critical role of innate immunity. Yet, understanding how neutrophils acquire tumour- promoting functions and how to counteract them is thus of great interest. We have previously reported that type I interferon (IFN) signalling enhances anti-tumourigenic properties of neutrophils. Our data from the first funding period suggest that this type I IFN-driven reprogramming may be initiated early during granulopoiesis. Notably, in cancer, downregulation of IFN signalling leads to tumour progression, suggesting that tumours may hijack granulopoiesis by actively dampening this pathway to skew neutrophil development toward pro-tumoural phenotypes. Building on these insights, we aim to investigate how type I IFN shapes neutrophil functional states in cancer by acting on early stages of granulopoiesis.
Team
Publications
Divergent Granulopoiesis at Extramedullary Sites Safeguards Antibacterial Host DefenseSilvestre-Roig, C.; Chevre, R.; Farjia, M.; Bender, A.; Vöcking, L. M.; Richter, M.; Hageb, A.; Suerdieck, V.; Arenas Cerro, F. J.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Tulotta, C.; Börgeling, Y.; Herrero-Cervera, A.; Flueter, H.; Reinartz Groba, S. N.; Ahern, D.; Osei-Sarpong, C.; Zimmer, R.; Alonso-Gonzalez, N.; Ortega, E.; Lienenklaus, S.; Kalinke, U.; Ludwig, S.; Engel, D. R.; Rosenbauer, F.; Monaco, C.; Dersch, P.; Kibler, A.; Cerutti, A.; Chavakis, T.; Benedito, R.; Hidalgo, A.; Jablonska, J.; Palomino-Segura, M.; Soehnlein, O.
2026 Sci Immunol
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Serpins A1/A3 within Tumor-Derived Extracellular Vesicles Support pro-Tumoral Bias of Neutrophils in CancerDomnich, M.; Pylaeva, E.; Siakaeva, E.; Kabankova, N.; Bedzinska, A.; Sojka, D.; Zebrowska, A.; Gawin, M.; Soldierer, M.; Rist, M.; Fochtman, D.; Ozel, I.; Giebel, B.; Helfrich, I.; Thiel, I.; Thakur, B. K.; Kürten, C. H. L.; Hanenberg, H.; Lang, S.; Ludwig, S.; Pietrowska, M.; Jablonska, J.
2025 bioRxiv
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Sex Differences in Neutrophil BiologyRichter, M.; Maier-Begandt, D.; Jablonska, J.; Silvestre-Roig, C.
2025 J Leukoc Biol
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Neutrophil-Specific Targeting of STAT3 Impairs Tumor Progression via the Expansion of Cytotoxic CD8+ T CellsOzel, I.; Sha, G.; Będzińska, A.; Pylaeva, E.; Naumova, Y.; Thiel, I.; Antczak, J.; Squire, A.; Gunzer, M.; Zelinskyy, G.; Kürten, C.; Lang, S.; Silvestre-Roig, C.; Kortylewski, M.; Granot, Z.; Jablonska, J.
2025 Signal Transduct Target Ther
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G-CSF/NAMPT Signaling Drives Neutrophil Dysfunction and Enhances Bacterial Infection Susceptibility in Cancer PatientsPylaeva, E.; Tollrian, L.; Riedesel, J.; Shevchuk, O.; Thiel, I.; Ozel, I.; Kabankova, N.; Voß, H.; Siebels, B.; Schlüter, H.; Haist, C.; Hanenberg, H.; Mattheis, S.; Kürten, C.; Sperandio, M.; Kehrmann, J.; Engel, D. R.; Lang, S.; Jablonska, J.
2025 Nat Commun
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Hypoxic-Ischemic Brain Injury in Neonatal Mice Sequentially Recruits Neutrophils with Dichotomous Phenotype and FunctionRichter, M.; Diesterbeck, E.; Pylaeva, E.; Labusek, N.; Köster, C.; Nagel, D.; Karsch, L.; Fischer, A. J.; Sous, M.; Jung, M.; Chevre, R.; Hagemann, N.; Andersson, E. A.; Ek, C. J.; Singh, V.; Hermann, D. M.; Gunzer, M.; Jablonska, J.; Felderhoff-Müser, U.; Bendix, I.; Soehnlein, O.; Herz, J.
2025 Nat Commun
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Gut Microbiota Deficiency Reduces Neutrophil Activation and Is Protective after Ischemic StrokeTuz, A. A.; Ghosh, S.; Karsch, L.; Antler, M.; Lakovic, V.; Lohmann, S.; Lehmann, A. H.; Beer, A.; Nagel, D.; Jung, M.; Hörenbaum, N.; Kaygusuz, V.; Qefalia, A.; Alshaar, B.; Amookazemi, N.; Bolsega, S.; Basic, M.; Siveke, J. T.; Heiles, S.; Grüneboom, A.; Lueong, S.; Herz, J.; Sickmann, A.; Hagemann, N.; Hasenberg, A.; Hermann, D. M.; Gunzer, M.; Singh, V.
2025 J Neuroinflammation
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Harnessing Myeloid Cells in CancerPark, S.-Y.; Pylaeva, E.; Bhuria, V.; Gambardella, A. R.; Schiavoni, G.; Mougiakakos, D.; Kim, S.-H.; Jablonska, J.
2025 Molecular Cancer
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Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after ischemic strokeTuz, A. A.; Hoerenbaum, N.; Ulusoy, Ö.; Ahmadi, A.; Gerlach, A.; Beer, A.; Kraus, A.; Hasenberg, A.; Hagemann, N.; Hermann, D. M.; Gunzer, M.; Singh, V.
2025 Front. Immunol.
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Proteomic Characterization of 1,000 Human and Murine Neutrophils Freshly Isolated from Blood and Sites of Sterile InflammationGhosh, S.; Tuz, A. A.; Stenzel, M.; Singh, V.; Richter, M.; Soehnlein, O.; Lange, E.; Heyer, R.; Cibir, Z.; Beer, A.; Jung, M.; Nagel, D.; Hermann, D. M.; Hasenberg, A.; Grüneboom, A.; Sickmann, A.; Gunzer, M.
2024 Mol Cell Proteomics
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrol Dial Transplant
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Sellhi neutrophils: a key to triumph in cancer therapyPylaeva, E.; Jablonska, J.
2023 Signal Transduct Target Ther
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Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionZec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R.
2023 Front Immunol
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Nonfunctional TGF-β/ALK1/ENG Signaling Pathway Supports Neutrophil Proangiogenic Activity in Hereditary Hemorrhagic Telangiectasia.Duerig, I.; Pylaeva, E.; Ozel, I.; Wainwright, S.; Thiel, I.; Bordbari, S.; Domnich, M.; Siakaeva, E.; Lakomek, A.; Toppe, F.; Schleupner, C.; Geisthoff, U.; Lang, S.; Droege, F.; Jablonska, J.
2023 J Leukoc Biol
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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanomaMartins Nascentes Melo, L.; Herrera-Rios, D.; Hinze, D.; Löffek, S.; Oezel, I.; Turiello, R.; Klein, J.; Leonardelli, S.; Westedt, I.-V.; Al-Matary, Y.; Egea-Rodriguez, S.; Brenzel, A.; Bau, M.; Sucker, A.; Hadaschik, E.; Wirsdörfer, F.; Hanenberg, H.; Uhlenbrock, N.; Rauh, D.; Poźniak, J.; Rambow, F.; Marine, J.-C.; Effern, M.; Glodde, N.; Schadendorf, D.; Jablonska, J.; Hölzel, M.; Helfrich, I.
2023 J Immunother Cancer
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During Early Stages of Cancer, Neutrophils Initiate Anti-Tumor Immune Responses in Tumor-Draining Lymph NodesPylaeva, E.; Korschunow, G.; Spyra, I.; Bordbari, S.; Siakaeva, E.; Ozel, I.; Domnich, M.; Squire, A.; Hasenberg, A.; Thangavelu, K.; Hussain, T.; Goetz, M.; Lang, K. S.; Gunzer, M.; Hansen, W.; Buer, J.; Bankfalvi, A.; Lang, S.; Jablonska, J.
2022 Cell Reports
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Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recoveryTuz, A. A.; Hasenberg, A.; Hermann, D. M.; Gunzer, M.; Singh, V.
2022 Front Immunol
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PMN-MDSC in newborns: Regulation of the regulators |