Cibir, Z.; Gunzer, M.

2024 Nat Rev Immunol

Autonomous migration is an essential immune cell function and has important roles in numerous diseases, for example, enabling neutrophils to access sites of infection. The ability to routinely measure or target immune cell migration would offer a wealth of clinical applications such as to predict adverse outcomes related to sepsis1 or the aggressiveness of human cancer2. Cell migration is most efficiently measured by time-lapse microscopy, but commercial video microscopes cannot generate enough videos to permit high-throughput analyses, making them unsuitable for clinical measurements. ComplexEye is a multi-lens array microscope that allows phenotypic high-throughput migration screens and routine migration analyses for clinical or experimental settings.