Neuro-Immune Crosstalk in Hematopoiesis, Inflammation, and Repair

Highlights

• The process of hematopoiesis, at steady state as well as during stress, is controlled by rhythmic/circadian sympathetic innervation.

• Nociception titrates the extent of myeloid cell influx to sites of inflammation and the ability of such cells to clear pathogens.

• Sympathetic innervation contributes to chronic inflammation, as in the case of atherosclerosis; it governs circadian and stress-induced arterial leukocyte recruitment and controls hematopoiesis that is accelerated by cardiovascular risk factors.

• Recent work provides increasing evidence of the importance of nociception in modulating tissue repair, including in epithelial surfaces.