Münter, D.; de Faria, F. W.; Richter, M.; Aranda-Pardos, I.; Hotfilder, M.; Walter, C.; Paga, E.; Inserte, C.; Albert, T. K.; Roy, R.; Rahman, S.; Riedel, N. C.; Müller, V.; Pascher, A.; Wiebe, K.; Schmid, I.; Vokuhl, C.; Winkler, B.; Jüttner, E.; Vieth, S.; Mücke, U.; Kluiver, T. A.; Peng, W. C.; Rossig, C.; Schlué, J.; Madadi-Sanjani, O.; Sandmann, S.; Hartmann, W.; A-Gonzalez, N.; Soehnlein, O.; Kerl, K.
Abstract
Background & Aims
Hepatoblastoma is the most common pediatric cancer of the liver and the majority of cases display activating mutations in the Wnt/β-catenin pathway. Understanding the complex milieu of the tumor microenvironment has resulted in promising new therapies for adult cancers, but similar approaches in pediatric cancers are still lacking. We aimed to provide a comprehensive analysis of the tumor microenvironment of hepatoblastoma unveiling its spatial architecture and key signaling mechanisms.