Deciphering molecular links between the tumour microenvironment and functional plasticity of tumour-associated neutrophils
A high intratumoural frequency of neutrophils (designated TAN) is associated with poor outcome in cancer patients. This project aims to identify the distinct mechanisms that regulate TAN recruitment and density in the tumour core and the tumour stroma. To this end, we will map the human tumour microenvironment by spatial omics analyses, relate this information with neutrophil counts and phenotype, and validate identified candidate molecules using in vitro and in vivo models. Thus, this project will identify clinically relevant factors that help to explain the well-documented tumour promoting function of TAN in the human oncology space.
Team
Publications
Controversies associated with the identification of the true origins of human neutrophilsSilvestre-Roig, C.; Brandau, S.
2024 Journal of Leukocyte Biology
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Mononuclear Myeloid Cells Can Shape Neutrophils in Brain Tumors. |
Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donorsPettinella, F.; Mariotti, B.; Lattanzi, C.; Bruderek, K.; Donini, M.; Costa, S.; Marini, O.; Iannoto, G.; Gasperini, S.; Caveggion, E.; Castellucci, M.; Calzetti, F.; Bianchetto-Aguilera, F.; Gardiman, E.; Giani, M.; Dusi, S.; Cantini, M.; Vassanelli, A.; Pavone, D.; Milella, M.; Pilotto, S.; Biondani, P.; Höing, B.; Schleupner, M. C.; Hussain, T.; Hadaschik, B.; Kaspar, C.; Visco, C.; Tecchio, C.; Koenderman, L.; Bazzoni, F.; Tamassia, N.; Brandau, S.; Cassatella, M. A.; Scapini, P.
2024 CR Med
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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HPV-Associated Head and Neck Cancer Is Characterized by Distinct Profiles of CD8+ T Cells and Myeloid-Derived Suppressor CellsKansy, B. A.; Wehrs, T. P.; Bruderek, K.; Si, Y.; Ludwig, S.; Droege, F.; Hasskamp, P.; Henkel, U.; Dominas, N.; Hoffmann, T. K.; Horn, P. A.; Schuler, M.; Gauler, T. C.; Lindemann, M.; Lang, S.; Bankfalvi, A.; Brandau, S.
2023 Cancer Immunol Immunother
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N1 versus N2 and PMN-MDSC: A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncologyAntuamwine, B. B.; Bosnjakovic, R.; Hofmann-Vega, F.; Wang, X.; Theodosiou, T.; Iliopoulos, I.; Brandau, S.
2022 Immunological Reviews
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PMN-MDSC in newborns: Regulation of the regulatorsJablonska, J.; Brandau, S.
2022 Journal of Leukocyte Biology
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Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human NeutrophilsSchirrmann, R.; Erkelenz, M.; Lamers, K.; Sritharan, O.; Nachev, M.; Sures, B.; Schlücker, S.; Brandau, S.
2022 American Chemical Society
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