Publications
Roadmap for Alleviating the Manifestations of Ageing in the Cardiovascular System.Liberale, L.; Tual-Chalot, S.; Sedej, S.; Ministrini, S.; Georgiopoulos, G.; Grunewald, M.; Bäck, M.; Bochaton-Piallat, M.-L.; Boon, R. A.; Ramos, G. C.; de Winther, M. P. J.; Drosatos, K.; Evans, P. C.; Ferguson, J. F.; Forslund-Startceva, S. K.; Goettsch, C.; Giacca, M.; Haendeler, J.; Kallikourdis, M.; Ketelhuth, D. F. J.; Koenen, R. R.; Lacolley, P.; Lutgens, E.; Maffia, P.; Miwa, S.; Monaco, C.; Montecucco, F.; Norata, G. D.; Osto, E.; Richardson, G. D.; Riksen, N. P.; Soehnlein, O.; Spyridopoulos, I.; Van Linthout, S.; Vilahur, G.; Wentzel, J. J.; Andrés, V.; Badimon, L.; Benetos, A.; Binder, C. J.; Brandes, R. P.; Crea, F.; Furman, D.; Gorbunova, V.; Guzik, T. J.; Hill, J. A.; Lüscher, T. F.; Mittelbrunn, M.; Nencioni, A.; Netea, M. G.; Passos, J. F.; Stamatelopoulos, K. S.; Tavernarakis, N.; Ungvari, Z.; Wu, J. C.; Kirkland, J. L.; Camici, G. G.; Dimmeler, S.; Kroemer, G.; Abdellatif, M.; Stellos, K.
2025 Nat Rev Cardiol
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Multiomic Analysis Uncovers a Continuous Spectrum of Differentiation and Wnt-MDK-Driven Immune Evasion in HepatoblastomaMünter, D.; de Faria, F. W.; Richter, M.; Aranda-Pardos, I.; Hotfilder, M.; Walter, C.; Paga, E.; Inserte, C.; Albert, T. K.; Roy, R.; Rahman, S.; Riedel, N. C.; Müller, V.; Pascher, A.; Wiebe, K.; Schmid, I.; Vokuhl, C.; Winkler, B.; Jüttner, E.; Vieth, S.; Mücke, U.; Kluiver, T. A.; Peng, W. C.; Rossig, C.; Schlué, J.; Madadi-Sanjani, O.; Sandmann, S.; Hartmann, W.; A-Gonzalez, N.; Soehnlein, O.; Kerl, K.
2025 Journal of Hepatology
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msiFlow: automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysisSpangenberg, P.; Bessler, S.; Widera, L.; Bottek, J.; Richter, M.; Thiebes, S.; Siemes, D.; Krauß, S. D.; Migas, L. G.; Kasarla, S. S.; Phapale, P.; Kleesiek, J.; Führer, D.; Moeller, L. C.; Heuer, H.; Van de Plas, R.; Gunzer, M.; Soehnlein, O.; Soltwisch, J.; Shevchuk, O.; Dreisewerd, K.; Engel, D. R.
2025 Nat Commun
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Altered shear stress of blood flow causes plasma membrane damage in endothelial cellsRaj, N.; Pan, C.; Starke, A. M.; L. Matos, A. L.; Soehnlein, O.; Gerke, V.
2025 Blood Vessels, Thrombosis & Hemostasis
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β-Glucan Reprograms Neutrophils to Promote Disease Tolerance against Influenza A VirusKhan, N.; Tran, K. A.; Chevre, R.; Locher, V.; Richter, M.; Sun, S.; Sadeghi, M.; Pernet, E.; Herrero-Cervera, A.; Grant, A.; Saif, A.; Downey, J.; Kaufmann, E.; Khader, S. A.; Joubert, P.; Barreiro, L. B.; Yipp, B. G.; Soehnlein, O.; Divangahi, M.
2025 Nat Immunol
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Mediterranean Diet, Neutrophil Count, and Carotid Intima-Media Thickness in Secondary Prevention: The CORDIOPREV StudyBoughanem, H.; Torres-Peña, J. D.; Arenas-de Larriva, A. P.; Romero-Cabrera, J. L.; Gómez-Luna, P.; Martín-Piedra, L.; Rodríguez-Cantalejo, F.; Tinahones, F. J.; Yubero Serrano, E. M.; Soehnlein, O.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2024 Eur Heart J
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Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence: Results From the CORDIOPREV StudyBoughanem, H.; de Larriva, A. P. A.; Camargo, A.; Torres-Peña, J. D.; Ojeda-Rodriguez, A.; Alcala-Diaz, J. F.; Romero-Cabrera, J. L.; Rangel-Zuñiga, O. A.; Rodríguez-Cantalejo, F.; Soehnlein, O.; Macias-Gonzalez, M.; Tinahones, F. J.; Perez-Martinez, P.; Delgado-Lista, J.; López-Miranda, J.
2024 The Journal of Clinical Endocrinology & Metabolism
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Intermittent High-Fat Diet: Atherosclerosis Progression by Neutrophil ReprogrammingHerrero-Cervera, A.; Chevre, R.; Soehnlein, O.
2024 Sig Transduct Target Ther
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Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profilesPajonczyk, D.; Sternschulte, M. F.; Soehnlein, O.; Bermudez, M.; Raabe, C. A.; Rescher, U.
2024 British Journal of Pharmacology
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Formyl Peptide Receptor 2 (FPR2) Regulates Dendritic Cell Metabolism and Th17 Cell Differentiation during NeuroinflammationLim, J.-H.; Neuwirth, A.; Chung, K.-J.; Grossklaus, S.; Soehnlein, O.; Hajishengallis, G.; Chavakis, T.
2024 Front. Immunol
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Neuro-Immune Crosstalk in Hematopoiesis, Inflammation, and RepairAkinyemi, D. E.; Chevre, R.; Soehnlein, O.
2024 Trends in Immunology
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Targeting Extranuclear Histones to Alleviate Acute and Chronic Inflammation.Nicolaes, G. A. F.; Soehnlein, O.
2024 Trends Pharmacol Sci
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Lack of Formyl-Peptide Receptor 1 Mitigates Atherosclerosis in Hyperlipidemic Mice |
Gasdermin D drives focal Crystalline Thrombotic Microangiopathy by accelerating Immunothrombosis and NecroinflammationWatanabe-Kusunoki, K.; Li, C.; Bandeira Honda, T. S.; Zhao, D.; Kusunoki, Y.; Ku, J.; Long, H.; Klaus, M.; Han, C.; Braun, A.; Mammadova-Bach, E.; Linkermann, A.; Van Avondt, K.; Richter, M.; Soehnlein, O.; Linder, M. I.; Klein, C.; Steiger, S.; Anders, H.-J.
2024 Blood
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Stroke and Myocardial Infarction Induce Neutrophil Extracellular Trap Release Disrupting Lymphoid Organ Structure and Immunoglobulin SecretionTuz, A. A.; Ghosh, S.; Karsch, L.; Ttoouli, D.; Sata, S. P.; Ulusoy, Ö.; Kraus, A.; Hoerenbaum, N.; Wolf, J.-N.; Lohmann, S.; Zwirnlein, F.; Kaygusuz, V.; Lakovic, V.; Tummes, H.-L.; Beer, A.; Gallert, M.; Thiebes, S.; Qefalia, A.; Cibir, Z.; Antler, M.; Korste, S.; Haj Yehia, E.; Michel, L.; Rassaf, T.; Kaltwasser, B.; Abdelrahman, H.; Mohamud Yusuf, A.; Wang, C.; Yin, D.; Haeusler, L.; Lueong, S.; Richter, M.; Engel, D. R.; Stenzel, M.; Soehnlein, O.; Frank, B.; Solo-Nomenjanahary, M.; Ho-Tin-Noé, B.; Siveke, J. T.; Totzeck, M.; Hoffmann, D.; Grüneboom, A.; Hagemann, N.; Hasenberg, A.; Desilles, J.-P.; Mazighi, M.; Sickmann, A.; Chen, J.; Hermann, D. M.; Gunzer, M.; Singh, V.
2024 Nat Cardiovasc Res
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease |
DRANquilizing neutrophil function in chronic liver diseaseGroba, S. R., & Soehnlein, O.
2023 Journal of Hepatology.
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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
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The Angiopoietin Receptor Tie2 Is Atheroprotective in Arterial EndotheliumAnisimov, A.; Fang, S.; Hemanthakumar, K. A.; Örd, T.; van Avondt, K.; Chevre, R.; Toropainen, A.; Singha, P.; Gilani, H.; Nguyen, S. D.; Karaman, S.; Korhonen, E. A.; Adams, R. H.; Augustin, H. G.; Öörni, K.; Soehnlein, O.; Kaikkonen, M. U.; Alitalo, K. 2023, 1–15.
2023 Nat Cardiovasc Res
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Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
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Hijacking CD177 for whole-body visualization of neutrophil dynamicsSoehnlein, O.
2023 Nature Cardiovascular Research
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Longitudinal in vivo monitoring of atheroprogression in hypercholesterolemic mice using photoacoustic imagingFerraro, B.; Giustetto, P.; Schengel, O.; Weckbach, L.; Maegdefessel, L.; Soehnlein, O.
2023 Thromb Haemost
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Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammationMauersberger, C.; Sager, H. B.; Wobst, J.; Dang, T. A.; Lambrecht, L.; Koplev, S.; Stroth, M.; Bettaga, N.; Schlossmann, J.; Wunder, F.; Friebe, A.; Björkegren, J. L. M.; Dietz, L.; Maas, S. L.; van der Vorst, E. P. C.; Sandner, P.; Soehnlein, O.; Schunkert, H.; Kessler, T.
2022 Nature Cardiovascular Research
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Neutrophils in aging and aging-related pathologiesVan Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O.
2022 Immunological Reviews
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AIMing 2 treat atherosclerosisSoehnlein, O.; Tall, A. R.
2022 Nature Reviews Cardiology
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Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formationSohrabi, Y.; Reinecke, H.; Soehnlein, O.
2022 Signal Transduction and Targeted Therapy
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