Neutrophil modulation during cerebral ischemia by the nuclear receptor NR4A1
Sterile inflammation upon cerebral ischemia is accompanied by immune cell infiltration. Neutrophils exert a crucial role within the inflammatory response and finally on neuronal damage via interaction with other immune cells of the innate and adaptive immune system. However, unselective blockade of brain neutrophil infiltration has so far been unsuccessful in clinical studies. We hypothesize that neutrophils are differentially modulated in the context of stroke, that the nuclear receptor NR4A1 is critically involved and that pharmacological modulation of NR4A1 opens the possibility of a fine-tuned therapeutic intervention.
Team
Publications
Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD MiceSchiffmann, D.; Lampkemeyer, V.; Lindner, M.; Fleck, A.-K.; Koch, K.; Eschborn, M.; Liebmann, M.; Strecker, J.-K.; Minnerup, J.; Wiendl, H.; Klotz, L.
2023 International Journal of Molecular Sciences
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on MonocytesRusso, A.; Schürmann, H.; Brandt, M.; Scholz, K.; Matos, A. L. L.; Grill, D.; Revenstorff, J.; Rembrink, M.; von Wulffen, M.; Fischer-Riepe, L.; Hanley, P. J.; Häcker, H.; Prünster, M.; Sánchez-Madrid, F.; Hermann, S.; Klotz, L.; Gerke, V.; Betz, T.; Vogl, T.; Roth, J.
2022 Advanced Science
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Neutrophils in aging and aging-related pathologiesVan Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O.
2022 Immunological Reviews
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