Macrophage regulation of neutrophil phenotype and function

Neutrophils are potent effector cells and therefore require precise regulation. Within organs, they quickly adopt tissue-dependent properties to serve specific physiological needs. Because neutrophils and macrophages frequently interact, we hypothesize that tissue-resident macrophages modulate neutrophil properties. Here, we will determine the impact of tissue macrophages on neutrophil phenotypes and functions, and characterize the potential role of the developmental origin of macrophages therein. Further, we will analyse the importance of macrophages for shaping neutrophil properties in a model of cardiac injury.

Schulz
Christian, MD

LMU

Medical Clinic I

Team

Kumaraswami
Konda, PhD student

LMU

Publications

A1 A2 A3 A4 A5 A6 A7 B1 B2 B3 B4 B5 C1 C2 C3 C5 AP1 Neutrophils - Biology and Diversity Maier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium. 2023 Nephrology Dialysis Transplantation https://doi.org/10.1093/ndt/gfad266
A6 Inflammaging aggravates stroke pathology Schulz, C.; Massberg, S. 2023 Nature immunology https://doi.org/10.1038/s41590-023-01516-y
A6 C2 C3 C6 A20 and the Noncanonical NF-κB Pathway Are Key Regulators of Neutrophil Recruitment during Fetal Ontogeny Rohwedder, I.; Wackerbarth, L. M.; Heinig, K.; Ballweg, A.; Altstätter, J.; Ripphahn, M.; Nussbaum, C.; Salvermoser, M.; Bierschenk, S.; Straub, T.; Gunzer, M.; Schmidt-Supprian, M.; Kolben, T.; Schulz, C.; Ma, A.; Walzog, B.; Heinig, M.; Sperandio, M. 2023 JCI Insight https://doi.org/10.1172/jci.insight.155968
A6 Glycolytic Side Pathways Regulating Macrophage Inflammatory Phenotypes and Functions Dionísio, F.; Tomas, L.; Schulz, C. 2023 Am J Physiol Cell Physiol https://doi.org/10.1152/ajpcell.00276.2022
A2 A6 B2 Z1 Neutrophils in aging and aging-related pathologies Van Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O. 2022 Immunological Reviews https://doi.org/10.1111/imr.13153
A6 Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease Petzold, T.; Zhang, Z.; Ballesteros, I.; Saleh, I.; Polzin, A.; Thienel, M.; Liu, L.; Ul Ain, Q.; Ehreiser, V.; Weber, C.; Kilani, B.; Mertsch, P.; Götschke, J.; Cremer, S.; Fu, W.; Lorenz, M.; Ishikawa-Ankerhold, H.; Raatz, E.; El-Nemr, S.; Görlach, A.; Marhuenda, E.; Stark, K.; Pircher, J.; Stegner, D.; Gieger, C.; Schmidt-Supprian, M.; Gaertner, F.; Almendros, I.; Kelm, M.; Schulz, C.; Hidalgo, A.; Massberg, S. 2022 Immunity https://doi.org/10.1016/j.immuni.2022.10.001