The role of the phosphatases CD45 and CD148 in the onset and progression of rheumatoid arthritis
Rheumatoid arthritis (RA) is an systemic autoimmune disorder characterized by chronic inflammation and synovial infiltration of immune cells. In the arthritic joint, neutrophils are the most abundant population. Phosphatases, and in particular CD45 and CD148, are key molecules in the regulation of neutrophils at the site of inflammation. This study will shed light on how CD45 and CD148 drive leukocyte recruitment during the different phases of arthritis and may hence lay the foundation for a therapeutic approach modulating neutrophil infiltration.
Team
Publications
RhoA GAP Myo9b Regulates Β2-Integrin Activity and Neutrophil Recruitment during Murine Acute Kidney Injury.Cappenberg, A.; Oguama, M.; Richter, M.; Margraf, A.; Amini, W.; Lindental, P.; Mersmann, S.; Bardel, B.; Block, H.; Vogl, T.; Soehnlein, O.; Ley, K.; Rossaint, J.; Zarbock, A.
2025 Blood
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Csk-Mediated Src Family Kinase Regulation Dampens Neutrophil Infiltration during Pulmonary Infection.Amini, W.; Schemmelmann, L.; Heming, J.-N.; Oguama, M.; Thomas, K.; Block, H.; Lindental, P.; Bardel, B.; Margraf, A.; Soehnlein, O.; Cappenberg, A.; Zarbock, A.
2025 JCI Insight
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Alveolar Epithelial and Vascular CXCR2 Mediates Transcytosis of CXCL1 in Inflamed Lungs.Thomas, K.; Rossaint, J.; Ludwig, N.; Mersmann, S.; Kötting, N.; Grenzheuser, J.; Schemmelmann, L.; Oguama, M.; Margraf, A.; Block, H.; Henke, K.; Hellenthal, K.; Mirakaj, V.; Gerke, V.; Hansen, U.; Gäher, K.; Engelhardt, M.; Roth, J.; Eble, J.; Hub, E.; Rot, A.; Alon, R.; Zarbock, A.
2025 Nat Commun
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Glutamine Modulates Neutrophil Recruitment and Effector Functions during Sterile InflammationHellenthal, K. E. M.; Thomas, K.; Ludwig, N.; Cappenberg, A.; Schemmelmann, L.; Tekath, T.; Margraf, A.; Mersmann, S.; Henke, K.; Rossaint, J.; Zarbock, A.; Amini, W.
2024 J Leukoc Biol
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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Nuclease Activity and Protein A Release of Staphylococcus Aureus Clinical Isolates Determine the Virulence in a Murine Model of Acute Lung Infection.Ludwig, N.; Thörner-van Almsick, J.; Mersmann, S.; Bardel, B.; Niemann, S.; Chasan, A. I.; Schäfers, M.; Margraf, A.; Rossaint, J.; Kahl, B. C.; Zarbock, A.; Block, H.
2023 Front Immunol
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Glutamine Prevents Acute Kidney Injury by Modulating Oxidative Stress and Apoptosis in Tubular Epithelial CellsThomas, K.; Zondler, L.; Ludwig, N.; Kardell, M.; Lüneburg, C.; Henke, K.; Mersmann, S.; Margraf, A.; Spieker, T.; Tekath, T.; Velic, A.; Holtmeier, R.; Hermann, J.; Jankowski, V.; Meersch, M.; Vestweber, D.; Westphal, M.; Roth, J.; Schäfers, M. A.; Kellum, J. A.; Lowell, C. A.; Rossaint, J.; Zarbock, A.
2022 JCI Insight
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