Metabolite-driven neutrophil dysfunction in sterile and non-sterile inflammation
Selected metabolites can regulate neutrophil functions in inflammation. Based on our preliminary data, we further explore the effects of soluble uric acid, an endogenous suppressor of neutrophil activation and migration, as well as the pro-inflammatory role of crystalline cholesterol, a known trigger of arterial immunothrombosis, in cholesterol crystal embolism-related kidney infarction and organ failure. We examine the impact of soluble uric acid on neutrophil function during non-sterile inflammation, e.g., in infection, and assess the effects of urate-lowering therapies and antibiotic-mediated suppression of the intestinal microbiota. In addition, we study the effects of soluble uric acid on neutrophils and platelets in immunothrombosis following non-sterile inflammation, as in infection and sterile inflammation, as in ischemic kidney infarction. Finally, we focus on the interplay between neutrophils and platelets during sterile inflammation, as in ischemic kidney infarction, namely, pyroptotic cell death and the cell type-specific contribution of gasdermin D in neutrophils versus platelets, in continuation of our previous work.
Team
Publications
CCR5 and CD74 Are Potential Therapeutic Targets for Necroinflammation in Preclinical Cholesterol Crystal EmbolismShi, C.; Wen, Z.; Zheng, K.; Li, B.; Miao, H.; Klinkhammer, B. M.; Boor, P.; Anders, H.-J.; Liu, D.
2026 Sci Transl Med
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Soluble Uric Acid Suppresses Neutrophil-Mediated Host Defense in SepsisLi, Q.; Anders, J.; Flora, K.; Ehreiser, L.; Wendling, C.; Zhang, F.; Chang, L.; Zhao, D.; Li, L.; Vogl, R.; Soehnlein, O.; Steiger, S.
2026 Nat Commun
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Dual Therapeutic Effects of Ultra‐Small Platinum‐Selenium Nanoparticles on Oxalate‐Induced Acute Kidney InjuryZheng, N.; Ma, Q.; Zhang, R.; Zhang, J.; Wang, Q.; He, Y.; Yang, B.; Steiger, S.; He, L.; Liu, S.
2026 Small
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Beyond Ion Flux: The Potassium Channel KV1.3 and Its Regulatory Function in NeutrophilsKu, J.; Anders, H.-J.; Sperandio, M.; Immler, R.
2026 Curr Opin Immunol
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Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNALi, C.; Marschner, J. A.; Kusunoki, Y.; Zhang, N.; Li, X.; Deng, H.; Zhao, Z.; Watanabe-Kusunoki, K.; Zhu, Z.; Xu, Y.; Steiger, S.; Lech, M.; Susztak, K.; Schulz, C.; Anders, H.-J.
2025 Adv Sci
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Converging Molecular Mechanisms of Nucleated Cell Death Pathways and Procoagulant Platelet FormationLi, C.; Braun, A.; Zu, J.; Gudermann, T.; Mammadova-Bach, E.; Anders, H.-J.
2025 Cells
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Oral Ketone Beta-Hydroxybutyrate Supplement Retards the Loss of Glomerular Filtration Rate in Alport Mice on Dual RAS/SGLT2 Blockade.Schreier, L. P.; Zhu, Z.; Kusunoki, Y.; Li, C.; Ku, J.; Klaus, M.; Anders, H.-J.
2025 Kidney360
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Podocyte A20/TNFAIP3 Controls Glomerulonephritis Severity via the Regulation of Inflammatory Responses and Effects on the CytoskeletonKöhler, P.; Ribeiro, A.; Honarpisheh, M.; von Rauchhaupt, E.; Lorenz, G.; Li, C.; Martin, L.; Steiger, S.; Lindenmeyer, M.; Schmaderer, C.; Anders, H.-J.; Thomasova, D.; Lech, M.
2025 Cells
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Inhibition of Complement Factor C5a or C5aR for Cholesterol Crystal Embolism-Related Vascular Thrombosis with Microvascular Injury and Its ConsequencesZhao, D.; Han, C.; Mammadova-Bach, E.; Watanabe-Kusunoki, K.; Honda, T. S. B.; Li, Y.; Li, C.; Li, Q.; Long, H.; Lyubenov, L.; Shi, C.; Santovito, D.; Weber, C.; Boor, P.; Droste, P.; Parikh, S.; Shapiro, J.; Chiara, L. D.; Carangelo, G.; Romagnani, P.; Klussmann, S.; Vater, A.; Anders, H.-J.
2024 Kidney Int
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Neutrophils and Extracellular Traps in Crystal-Associated DiseasesMa, Q.; Steiger, S.
2024 Trends Mol Med
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Gasdermin D drives focal Crystalline Thrombotic Microangiopathy by accelerating Immunothrombosis and NecroinflammationWatanabe-Kusunoki, K.; Li, C.; Bandeira Honda, T. S.; Zhao, D.; Kusunoki, Y.; Ku, J.; Long, H.; Klaus, M.; Han, C.; Braun, A.; Mammadova-Bach, E.; Linkermann, A.; Van Avondt, K.; Richter, M.; Soehnlein, O.; Linder, M. I.; Klein, C.; Steiger, S.; Anders, H.-J.
2024 Blood
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrol Dial Transplant
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Finerenone Added to RAS/SGLT2 Blockade for Chronic Kidney Disease in Alport Syndrome. Results of a Randomized Controlled Trial with Col4a3-/- MiceZhu, Z.; Rosenkranz, K. A.; Kusunoki, Y.; Li, C.; Klaus, M.; Gross, O.; Angelotti, M.-L.; Antonelli, G.; Cirillo, L.; Romagnani, P.; Bouteldja, N.; Sadr, A. V.; Bülow, R. D.; Boor, P.; Anders, H.-J.
2023 J Am Soc Nephrol
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Asymptomatic Hyperuricaemia in Chronic Kidney Disease: Mechanisms and Clinical Implications. |
The Five Types of Glomerulonephritis Classified by Pathogenesis, Activity, and Chronicity (GN-AC)Romagnani, P.; Kitching, A. R.; Leung, N.; Anders, H.-J.
2023 Nephrol Dial Transplant
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Neutrophil circadian rhythm is associated with different outcomes of acute kidney injury due to cholesterol crystal embolismShi, C.; Zhao, D.; Lyubenov, L.; Motrapu, M.; Li, N.; Steiger, S.; Mammadova-Bach, E.; Yang, L.; Liu, D.; Anders, H.-J.
2022 Front Cardiovasc Med
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