Role of α-actinin in neutrophil recruitment and neutrophil effector function
Rheumatoid arthritis (RA) is an systemic autoimmune disorder characterized by chronic inflammation and synovial infiltration of immune cells. In the arthritic joint, neutrophils are the most abundant population. Phosphatases, and in particular CD45 and CD148, are key molecules in the regulation of neutrophils at the site of inflammation. This study will shed light on how CD45 and CD148 drive leukocyte recruitment during the different phases of arthritis and may hence lay the foundation for a therapeutic approach modulating neutrophil infiltration.
Team
Publications
Integrin Activation by Two Independently Regulated Calcium-Mediated Pathways Is Required for Neutrophil RecruitmentOguama, M.; Lindental, P.; Clemens, R. A.; Lowell, C. A.; Soehnlein, O.; Roth, J.; Bakchoul, T.; Cappenberg, A.; Zarbock, A.
2026 Cell Commun Signal
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The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke SeverityStrecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J.
2025 bioRxiv
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Neutrophil Progenitor Mobilization Is a Distinct Feature of STEMI and Predicts SurvivalRichter, M.; Von Göwels*, J.; Fähndrich*, M.; Fernandez*, C. L.; Grohn*, K.; Schwarz, D.; Lang, A.; Polzin, A.; Farinola, L.; Gosh, S.; Groba, S. R.; Heming, J.-N.; Aleth, H.; Rübsamen, N.; Radecke, T.; Rosenbauer, F.; Sickmann, A.; Karch, A.; Zarbock, A.; Minnerup, J.; Sindermann, J.; Bender, A.; Rossaint, J.; Ormanns, S.; Gunzer, M.; Reinecke, H.; Makowski, L.; Jung, C.; Silvestre-Roig, C.; Kelm, M.; Gerdes, N.; Chevre, R.; Lange, S.; Soehnlein, O.
2025 Research Square
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CD45 and CD148 Are Critically Involved in Neutrophil Recruitment and Function During Inflammatory Arthritis in MiceHeming, J.-N.; Margraf, A.; Najder, K.; Germena, G.; Richter, M.; Cappenberg, A.; Henke, K.; Bardel, B.; Schemmelmann, L.; Oguama, M.; Lindental, P.; Amini, W.; Sobocik, J.; Schett, G.; Krönke, G.; Block, H.; Rossaint, J.; Soehnlein, O.; Zarbock, A.
2025 Cells
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RhoA GAP Myo9b Regulates Β2-Integrin Activity and Neutrophil Recruitment during Murine Acute Kidney InjuryCappenberg, A.; Oguama, M.; Richter, M.; Margraf, A.; Amini, W.; Lindental, P.; Mersmann, S.; Bardel, B.; Block, H.; Vogl, T.; Soehnlein, O.; Ley, K.; Rossaint, J.; Zarbock, A.
2025 Blood
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Csk-Mediated Src Family Kinase Regulation Dampens Neutrophil Infiltration during Pulmonary InfectionAmini, W.; Schemmelmann, L.; Heming, J.-N.; Oguama, M.; Thomas, K.; Block, H.; Lindental, P.; Bardel, B.; Margraf, A.; Soehnlein, O.; Cappenberg, A.; Zarbock, A.
2025 JCI Insight
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Alveolar Epithelial and Vascular CXCR2 Mediates Transcytosis of CXCL1 in Inflamed LungsThomas, K.; Rossaint, J.; Ludwig, N.; Mersmann, S.; Kötting, N.; Grenzheuser, J.; Schemmelmann, L.; Oguama, M.; Margraf, A.; Block, H.; Henke, K.; Hellenthal, K.; Mirakaj, V.; Gerke, V.; Hansen, U.; Gäher, K.; Engelhardt, M.; Roth, J.; Eble, J.; Hub, E.; Rot, A.; Alon, R.; Zarbock, A.
2025 Nat Commun
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Glutamine Modulates Neutrophil Recruitment and Effector Functions during Sterile InflammationHellenthal, K. E. M.; Thomas, K.; Ludwig, N.; Cappenberg, A.; Schemmelmann, L.; Tekath, T.; Margraf, A.; Mersmann, S.; Henke, K.; Rossaint, J.; Zarbock, A.; Amini, W.
2024 J Leukoc Biol
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrol Dial Transplant
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Nuclease Activity and Protein A Release of Staphylococcus Aureus Clinical Isolates Determine the Virulence in a Murine Model of Acute Lung Infection.Ludwig, N.; Thörner-van Almsick, J.; Mersmann, S.; Bardel, B.; Niemann, S.; Chasan, A. I.; Schäfers, M.; Margraf, A.; Rossaint, J.; Kahl, B. C.; Zarbock, A.; Block, H.
2023 Front Immunol
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Glutamine Prevents Acute Kidney Injury by Modulating Oxidative Stress and Apoptosis in Tubular Epithelial CellsThomas, K.; Zondler, L.; Ludwig, N.; Kardell, M.; Lüneburg, C.; Henke, K.; Mersmann, S.; Margraf, A.; Spieker, T.; Tekath, T.; Velic, A.; Holtmeier, R.; Hermann, J.; Jankowski, V.; Meersch, M.; Vestweber, D.; Westphal, M.; Roth, J.; Schäfers, M. A.; Kellum, J. A.; Lowell, C. A.; Rossaint, J.; Zarbock, A.
2022 JCI Insight
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