Deciphering molecular links between the tumour microenvironment and functional plasticity of tumour-associated neutrophils


A high intratumoural frequency of neutrophils (designated TAN) is associated with poor outcome in cancer patients. This project aims to identify the distinct mechanisms that regulate TAN recruitment and density in the tumour core and the tumour stroma. To this end, we will map the human tumour microenvironment by spatial omics analyses, relate this information with neutrophil counts and phenotype, and validate identified candidate molecules using in vitro and in vivo models. Thus, this project will identify clinically relevant factors that help to explain the well-documented tumour promoting function of TAN in the human oncology space.



Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors

Pettinella, F.; Mariotti, B.; Lattanzi, C.; Bruderek, K.; Donini, M.; Costa, S.; Marini, O.; Iannoto, G.; Gasperini, S.; Caveggion, E.; Castellucci, M.; Calzetti, F.; Bianchetto-Aguilera, F.; Gardiman, E.; Giani, M.; Dusi, S.; Cantini, M.; Vassanelli, A.; Pavone, D.; Milella, M.; Pilotto, S.; Biondani, P.; Höing, B.; Schleupner, M. C.; Hussain, T.; Hadaschik, B.; Kaspar, C.; Visco, C.; Tecchio, C.; Koenderman, L.; Bazzoni, F.; Tamassia, N.; Brandau, S.; Cassatella, M. A.; Scapini, P.

2024 CR Med

Neutrophils - Biology and Diversity

Maier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.

2023 Nephrology Dialysis Transplantation