Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease |
Sellhi neutrophils: a key to triumph in cancer therapyPylaeva, E.; Jablonska, J.
2023 Signal Transduction and Targeted Therapy
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E-Selectin-Mediated Rapid NLRP3 Inflammasome Activation Regulates S100A8/S100A9 Release from Neutrophils via Transient Gasdermin D Pore Formation.Pruenster, M.; Immler, R.; Roth, J.; Kuchler, T.; Bromberger, T.; Napoli, M.; Nussbaumer, K.; Rohwedder, I.; Wackerbarth, L. M.; Piantoni, C.; Hennis, K.; Fink, D.; Kallabis, S.; Schroll, T.; Masgrau-Alsina, S.; Budke, A.; Liu, W.; Vestweber, D.; Wahl-Schott, C.; Roth, J.; Meissner, F.; Moser, M.; Vogl, T.; Hornung, V.; Broz, P.; Sperandio, M.
2023 Nat Immunol
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Nuclease Activity and Protein A Release of Staphylococcus Aureus Clinical Isolates Determine the Virulence in a Murine Model of Acute Lung Infection.Ludwig, N.; Thörner-van Almsick, J.; Mersmann, S.; Bardel, B.; Niemann, S.; Chasan, A. I.; Schäfers, M.; Margraf, A.; Rossaint, J.; Kahl, B. C.; Zarbock, A.; Block, H.
2023 Front Immunol
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Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionZec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R.
2023 Front. Immunol.
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Externalized Histones Fuel Pulmonary Fibrosis via a Platelet-Macrophage Circuit of TGFβ1 and IL-27Riehl, D. R.; Sharma, A.; Roewe, J.; Murke, F.; Ruppert, C.; Eming, S. A.; Bopp, T.; Kleinert, H.; Radsak, M. P.; Colucci, G.; Subramaniam, S.; Reinhardt, C.; Giebel, B.; Prinz, I.; Guenther, A.; Strand, D.; Gunzer, M.; Waisman, A.; Ward, P. A.; Ruf, W.; Schäfer, K.; Bosmann, M.
2023 Proceedings of the National Academy of Sciences
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Visualization of Metabolites and Microbes at High Spatial Resolution Using MALDI Mass Spectrometry Imaging and in Situ Fluorescence Labeling.Bourceau, P.; Geier, B.; Suerdieck, V.; Bien, T.; Soltwisch, J.; Dreisewerd, K.; Liebeke, M.
2023 Nat Protoc
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S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritisvon Wulffen, M.; Luehrmann, V.; Robeck, S.; Russo, A.; Fischer-Riepe, L.; van den Bosch, M.; van Lent, P.; Loser, K.; Gabrilovich, D. I.; Hermann, S.; Roth, J.; Vogl, T.
2023 Cell Reports
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DRANquilizing neutrophil function in chronic liver diseaseGroba, S. R., & Soehnlein, O.
2023 Journal of Hepatology.
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Non-functional TGF-β/ALK1/ENG Signaling Pathway supports neutrophil pro-angiogenic activity in Hereditary Hemorrhagic TelangiectasiaDuerig, I., Pylaeva, E., Ozel, I., Weinwright, S., Thiel, I., Bordbari, S., Domnich, M., Siakaeva, E., Lakomek, A., Toppe, F., Schleupner, C., Geisthoff, U., Lang, S., Droege, F., & Jablonska, J.
2023 Journal of leukocyte biology
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Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry ImagingBessler, S.; Soltwisch, J.; Dreisewerd, K.
2023 Anal. Chem.
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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanomaMartins Nascentes Melo, L.; Herrera-Rios, D.; Hinze, D.; Löffek, S.; Oezel, I.; Turiello, R.; Klein, J.; Leonardelli, S.; Westedt, I.-V.; Al-Matary, Y.; Egea-Rodriguez, S.; Brenzel, A.; Bau, M.; Sucker, A.; Hadaschik, E.; Wirsdörfer, F.; Hanenberg, H.; Uhlenbrock, N.; Rauh, D.; Poźniak, J.; Rambow, F.; Marine, J.-C.; Effern, M.; Glodde, N.; Schadendorf, D.; Jablonska, J.; Hölzel, M.; Helfrich, I.
2023 J Immunother Cancer
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Finerenone Added to RAS/SGLT2 Blockade for Chronic Kidney Disease in Alport Syndrome. Results of a Randomized Controlled Trial with Col4a3-/- Mice.Zhu, Z.; Rosenkranz, K. A.; Kusunoki, Y.; Li, C.; Klaus, M.; Gross, O.; Angelotti, M.-L.; Antonelli, G.; Cirillo, L.; Romagnani, P.; Bouteldja, N.; Sadr, A. V.; Bülow, R. D.; Boor, P.; Anders, H.-J.
2023 J Am Soc Nephrol
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Asymptomatic Hyperuricaemia in Chronic Kidney Disease: Mechanisms and Clinical Implications. |
The Five Types of Glomerulonephritis Classified by Pathogenesis, Activity, and Chronicity (GN-AC)Romagnani, P.; Kitching, A. R.; Leung, N.; Anders, H.-J.
2023 Nephrol Dial Transplant
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Inflammaging aggravates stroke pathology |
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammationGatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.
2023 Immunity
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The Roles of Toll-like Receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for Monocyte Activation by the DAMP S100A8/S100A9Möller, A.; Jauch-Speer, S.-L.; Gandhi, S.; Vogl, T.; Roth, J.; Fehler, O.
2023 Front Immunol
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S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of LeukocytesWolf, M.; Joseph, R.; Austermann, J.; Scharrnbeck-Davis, C.; Hermann, S.; Roth, J.; Vogl, T.
2023 Biomedicines
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Macrophage Function in Adipose Tissue Homeostasis and Metabolic InflammationChavakis, T.; Alexaki, V. I.; Ferrante, A. W.
2023 Nat Immunol
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Rapid and Fully Automated Blood Vasculature Analysis in 3D Light-Sheet Image Volumes of Different OrgansSpangenberg, P.; Hagemann, N.; Squire, A.; Förster, N.; Krauß, S. D.; Qi, Y.; Yusuf, A. M.; Wang, J.; Grüneboom, A.; Kowitz, L.; Korste, S.; Totzeck, M.; Cibir, Z.; Tuz, A. A.; Singh, V.; Siemes, D.; Struensee, L.; Engel, D. R.; Ludewig, P.; Nascentes Melo, L. M.; Helfrich, I.; Chen, J.; Gunzer, M.; Hermann, D. M.; Mosig, A.
2023 Cell Reports Methods
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The Angiopoietin Receptor Tie2 Is Atheroprotective in Arterial EndotheliumAnisimov, A.; Fang, S.; Hemanthakumar, K. A.; Örd, T.; van Avondt, K.; Chevre, R.; Toropainen, A.; Singha, P.; Gilani, H.; Nguyen, S. D.; Karaman, S.; Korhonen, E. A.; Adams, R. H.; Augustin, H. G.; Öörni, K.; Soehnlein, O.; Kaikkonen, M. U.; Alitalo, K. 2023, 1–15.
2023 Nat Cardiovasc Res
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A20 and the Noncanonical NF-κB Pathway Are Key Regulators of Neutrophil Recruitment during Fetal OntogenyRohwedder, I.; Wackerbarth, L. M.; Heinig, K.; Ballweg, A.; Altstätter, J.; Ripphahn, M.; Nussbaum, C.; Salvermoser, M.; Bierschenk, S.; Straub, T.; Gunzer, M.; Schmidt-Supprian, M.; Kolben, T.; Schulz, C.; Ma, A.; Walzog, B.; Heinig, M.; Sperandio, M.
2023 JCI Insight
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Analyzing Mitochondrial Respiration of Human Induced Pluripotent Stem Cell-Derived Myeloid Progenitors Using Seahorse TechnologyFan, Y.; Mizoguchi, Y.; Tatematsu, M.; Linder, M. I.; Frenz, S.; Choi, J.; Klein, C.
2023 STAR Protoc
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Complex Regulation of Alarmins S100A8/A9 and Secretion via Gasdermin-D Pores Exacerbates Autoinflammation in Familial Mediterranean FeverJorch, S. K.; McNally, A.; Berger, P.; Wolf, J.; Kaiser, K.; Chetrusca Covash, A.; Robeck, S.; Pastau, I.; Fehler, O.; Jauch-Speer, S.-L.; Hermann, S.; Schäfers, M.; Van Gorp, H.; Kanneganti, A.; Dehoorne, J.; Haerynck, F.; Penco, F.; Gattorno, M.; Chae, J. J.; Kubes, P.; Lamkanfi, M.; Wullaert, A.; Sperandio, M.; Vogl, T.; Roth, J.; Austermann, J.
2023 J Allergy Clin Immunol
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Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic MicePan, C.; Herrero-Fernandez, B.; Borja Almarcha, C.; Gomez Bris, R.; Zorita, V.; Sáez, A.; Maas, S. L.; Pérez-Olivares, L.; Herrero-Cervera, A.; Lemnitzer, P.; van Avondt, K.; Silvestre-Roig, C.; Gonzalez-Granado, J. M.; Chevre, R.; Soehnlein, O.
2023 Circulation
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Targeting Neutrophil Extracellular Traps (NETs) Ameliorates Inflammation in Murine Psoriasiform DermatitisHollstein, M. M.; Manzke, V.; Scheidmann, S. E. F.; Schrenker, S.; Schaffrinski, M.; Neubert, E.; Kramer, D.; Raker, V. K.; Schön, M. P.; Erpenbeck, L.
2023 Journal of Dermatological Science
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Glycolytic Side Pathways Regulating Macrophage Inflammatory Phenotypes and FunctionsDionísio, F.; Tomas, L.; Schulz, C.
2023 Am J Physiol Cell Physiol
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Non-Invasive Mapping of Systemic Neutrophil Dynamics upon Cardiovascular InjuryBouvain, P.; Ding, Z.; Kadir, S.; Kleimann, P.; Kluge, N.; Tiren, Z.-B.; Steckel, B.; Flocke, V.; Zalfen, R.; Petzsch, P.; Wachtmeister, T.; John, G.; Subramaniam, N.; Krämer, W.; Strasdeit, T.; Mehrabipour, M.; Moll, J. M.; Schubert, R.; Ahmadian, M. R.; Bönner, F.; Boeken, U.; Westenfeld, R.; Engel, D. R.; Kelm, M.; Schrader, J.; Köhrer, K.; Grandoch, M.; Temme, S.; Flögel, U.
2023 Nature Cardiovascular Research
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Hijacking CD177 for whole-body visualization of neutrophil dynamicsSoehnlein, O.
2023 Nature Cardiovascular Research
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Longitudinal in vivo monitoring of atheroprogression in hypercholesterolemic mice using photoacoustic imagingFerraro, B.; Giustetto, P.; Schengel, O.; Weckbach, L.; Maegdefessel, L.; Soehnlein, O.
2023 Thromb Haemost
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Human Genetic Defects in SRP19 and SRPRA Cause Severe Congenital Neutropenia with Distinctive Proteome ChangesLinder, M. I.; Mizoguchi, Y.; Hesse, S.; Csaba, G.; Tatematsu, M.; Łyszkiewicz, M.; Zietara, N.; Jeske, T.; Hastreiter, M.; Rohlfs, M.; Liu, Y.; Grabowski, P.; Ahomaa, K.; Maier-Begandt, D.; Schwestka, M.; Pazhakh, V.; Isiaku, A.; Briones Miranda, B.; Blombery, P.; Saito, M. K.; Rusha, E.; Alizadeh, Z.; Pourpak, Z.; Kobayashi, M.; Rezaei, N.; Unal, E.; Hauck, F.; Drukker, M.; Walzog, B.; Rappsilber, J.; Zimmer, R.; Lieschke, G. J.; Klein, C.
2023 Blood
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During Early Stages of Cancer, Neutrophils Initiate Anti-Tumor Immune Responses in Tumor-Draining Lymph NodesPylaeva, E.; Korschunow, G.; Spyra, I.; Bordbari, S.; Siakaeva, E.; Ozel, I.; Domnich, M.; Squire, A.; Hasenberg, A.; Thangavelu, K.; Hussain, T.; Goetz, M.; Lang, K. S.; Gunzer, M.; Hansen, W.; Buer, J.; Bankfalvi, A.; Lang, S.; Jablonska, J.
2022 Cell Reports
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Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammationMauersberger, C.; Sager, H. B.; Wobst, J.; Dang, T. A.; Lambrecht, L.; Koplev, S.; Stroth, M.; Bettaga, N.; Schlossmann, J.; Wunder, F.; Friebe, A.; Björkegren, J. L. M.; Dietz, L.; Maas, S. L.; van der Vorst, E. P. C.; Sandner, P.; Soehnlein, O.; Schunkert, H.; Kessler, T.
2022 Nature Cardiovascular Research
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N1 versus N2 and PMN-MDSC: A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncologyAntuamwine, B. B.; Bosnjakovic, R.; Hofmann-Vega, F.; Wang, X.; Theodosiou, T.; Iliopoulos, I.; Brandau, S.
2022 Immunological Reviews
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Expansion microscopy of neutrophil nuclear structure and extracellular trapsHolsapple, J. S.; Schnitzler, L.; Rusch, L.; Baldeweg, T. H.; Neubert, E.; Kruss, S.; Erpenbeck, L.
2022 Biophysical Reports
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Role of S100A8/A9 in Platelet–Neutrophil Complex Formation during Acute InflammationRevenstorff, J.; Ludwig, N.; Hilger, A.; Mersmann, S.; Lehmann, M.; Grenzheuser, J. C.; Kardell, M.; Bone, J.; Kötting, N. M.; Marx, N. C.; Roth, J.; Vogl, T.; Rossaint, J.
2022 Cells
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Pathological neutrophil migration predicts adverse outcomes in hospitalized patients with liver cirrhosisLanger, M.-M.; Sichelschmidt, S.; Bauschen, A.; Bornemann, L.; Guckenbiehl, S.; Gunzer, M.; Lange, C. M.
2022 Liver International
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Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recoveryTuz, A. A.; Hasenberg, A.; Hermann, D. M.; Gunzer, M.; Singh, V.
2022 Frontiers in Immunology
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Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on MonocytesRusso, A.; Schürmann, H.; Brandt, M.; Scholz, K.; Matos, A. L. L.; Grill, D.; Revenstorff, J.; Rembrink, M.; von Wulffen, M.; Fischer-Riepe, L.; Hanley, P. J.; Häcker, H.; Prünster, M.; Sánchez-Madrid, F.; Hermann, S.; Klotz, L.; Gerke, V.; Betz, T.; Vogl, T.; Roth, J.
2022 Advanced Science
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Neutrophils in aging and aging-related pathologiesVan Avondt, K.; Strecker, J.-K.; Tulotta, C.; Minnerup, J.; Schulz, C.; Soehnlein, O.
2022 Immunological Reviews
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Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular diseasePetzold, T.; Zhang, Z.; Ballesteros, I.; Saleh, I.; Polzin, A.; Thienel, M.; Liu, L.; Ul Ain, Q.; Ehreiser, V.; Weber, C.; Kilani, B.; Mertsch, P.; Götschke, J.; Cremer, S.; Fu, W.; Lorenz, M.; Ishikawa-Ankerhold, H.; Raatz, E.; El-Nemr, S.; Görlach, A.; Marhuenda, E.; Stark, K.; Pircher, J.; Stegner, D.; Gieger, C.; Schmidt-Supprian, M.; Gaertner, F.; Almendros, I.; Kelm, M.; Schulz, C.; Hidalgo, A.; Massberg, S.
2022 Immunity
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The Role of Neutrophils in Trained ImmunityKalafati, L.; Hatzioannou, A.; Hajishengallis, G.; Chavakis, T.
2022 Immunological Reviews
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Glutamine Prevents Acute Kidney Injury by Modulating Oxidative Stress and Apoptosis in Tubular Epithelial CellsThomas, K.; Zondler, L.; Ludwig, N.; Kardell, M.; Lüneburg, C.; Henke, K.; Mersmann, S.; Margraf, A.; Spieker, T.; Tekath, T.; Velic, A.; Holtmeier, R.; Hermann, J.; Jankowski, V.; Meersch, M.; Vestweber, D.; Westphal, M.; Roth, J.; Schäfers, M. A.; Kellum, J. A.; Lowell, C. A.; Rossaint, J.; Zarbock, A.
2022 JCI Insight
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PMN-MDSC in newborns: Regulation of the regulatorsJablonska, J.; Brandau, S.
2022 Journal of Leukocyte Biology
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Neutrophil circadian rhythm is associated with different outcomes of acute kidney injury due to cholesterol crystal embolismShi, C.; Zhao, D.; Lyubenov, L.; Motrapu, M.; Li, N.; Steiger, S.; Mammadova-Bach, E.; Yang, L.; Liu, D.; Anders, H.-J.
2022 Frontiers in Cardiovascular Medicine
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AIMing 2 treat atherosclerosisSoehnlein, O.; Tall, A. R.
2022 Nature Reviews Cardiology
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Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formationSohrabi, Y.; Reinecke, H.; Soehnlein, O.
2022 Signal Transduction and Targeted Therapy
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Mechanisms and Therapeutic Modulation of Neutrophil-Mediated InflammationHajishengallis, G.; Chavakis, T.
2022 Journal of Dental Research
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Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human NeutrophilsSchirrmann, R.; Erkelenz, M.; Lamers, K.; Sritharan, O.; Nachev, M.; Sures, B.; Schlücker, S.; Brandau, S.
2022 American Chemical Society
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