The functional output of neutrophils including their recruitment to tissues, their extrusion of NETs and their death and subsequent clearance is of primary importance for the design of therapeutic interference strategies. Hence, projects defined in project area C will not just reveal refined understanding of neutrophil function but also provide a translational link with assessment of preclinical intervention approaches some of which are consolidated by the integration of analyses of patient samples. In addition, we will implement preclinical randomized controlled bi-/multi-centre trials on disease models available in more than one partner sites including stroke and arthritis models.