Impact of type I interferons on tumour-dependent granulopoiesis and neutrophil tumourigenicity
The aim of this proposal is to unravel the role of IFN receptor (IFNAR1) in the development of tumour-associated neutrophils. As lack of IFNAR1 leads to pro-tumour activity of neutrophils and as IFNAR1 expression is significantly downregulated in the tumour microenvironment, we hypothesize that the tumour actively disturbs IFNAR1 signalling to support the development of pro-tumour neutrophils. Bearing this in mind, we aim to identify the molecular mechanisms involved in the development of neutrophils in IFNAR1 deficiency, thus potentially identifying novel therapeutic targets that allow to reverse the pro-tumour bias of neutrophils.
Team
Publications
Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrology Dialysis Transplantation
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Sellhi neutrophils: a key to triumph in cancer therapyPylaeva, E.; Jablonska, J.
2023 Signal Transduction and Targeted Therapy
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Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionZec, K.; Thiebes, S.; Bottek, J.; Siemes, D.; Spangenberg, P.; Trieu, D. V.; Kirstein, N.; Subramaniam, N.; Christ, R.; Klein, D.; Jendrossek, V.; Loose, M.; Wagenlehner, F.; Jablonska, J.; Bracht, T.; Sitek, B.; Budeus, B.; Klein-Hitpass, L.; Theegarten, D.; Shevchuk, O.; Engel, D. R.
2023 Front. Immunol.
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Non-functional TGF-β/ALK1/ENG Signaling Pathway supports neutrophil pro-angiogenic activity in Hereditary Hemorrhagic TelangiectasiaDuerig, I., Pylaeva, E., Ozel, I., Weinwright, S., Thiel, I., Bordbari, S., Domnich, M., Siakaeva, E., Lakomek, A., Toppe, F., Schleupner, C., Geisthoff, U., Lang, S., Droege, F., & Jablonska, J.
2023 Journal of leukocyte biology
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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanomaMartins Nascentes Melo, L.; Herrera-Rios, D.; Hinze, D.; Löffek, S.; Oezel, I.; Turiello, R.; Klein, J.; Leonardelli, S.; Westedt, I.-V.; Al-Matary, Y.; Egea-Rodriguez, S.; Brenzel, A.; Bau, M.; Sucker, A.; Hadaschik, E.; Wirsdörfer, F.; Hanenberg, H.; Uhlenbrock, N.; Rauh, D.; Poźniak, J.; Rambow, F.; Marine, J.-C.; Effern, M.; Glodde, N.; Schadendorf, D.; Jablonska, J.; Hölzel, M.; Helfrich, I.
2023 J Immunother Cancer
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During Early Stages of Cancer, Neutrophils Initiate Anti-Tumor Immune Responses in Tumor-Draining Lymph NodesPylaeva, E.; Korschunow, G.; Spyra, I.; Bordbari, S.; Siakaeva, E.; Ozel, I.; Domnich, M.; Squire, A.; Hasenberg, A.; Thangavelu, K.; Hussain, T.; Goetz, M.; Lang, K. S.; Gunzer, M.; Hansen, W.; Buer, J.; Bankfalvi, A.; Lang, S.; Jablonska, J.
2022 Cell Reports
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Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recoveryTuz, A. A.; Hasenberg, A.; Hermann, D. M.; Gunzer, M.; Singh, V.
2022 Frontiers in Immunology
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PMN-MDSC in newborns: Regulation of the regulatorsJablonska, J.; Brandau, S.
2022 Journal of Leukocyte Biology
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