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Organ-specific priming during granulopoiesis generates neutrophil subsets

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Neutrophils are traditionally been looked upon as a homogenous population of short-lived, end-differentiated, and transcriptionally silent leukocytes. In this project, we will develop a concept of neutrophil heterogeneity based on the organ-dependent specification of neutrophil progenitors to differentiate into distinct neutrophil lineages. Multi-omics analyses and functional studies will reveal the contribution of splenic and bone marrow neutrophils to regulation of the immune response and tissue damage during inflammation.

Team

Publications

Divergent Granulopoiesis at Extramedullary Sites Safeguards Antibacterial Host Defense

Silvestre-Roig, C.; Chevre, R.; Farjia, M.; Bender, A.; Vöcking, L. M.; Richter, M.; Hageb, A.; Suerdieck, V.; Arenas Cerro, F. J.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Tulotta, C.; Börgeling, Y.; Herrero-Cervera, A.; Flueter, H.; Reinartz Groba, S. N.; Ahern, D.; Osei-Sarpong, C.; Zimmer, R.; Alonso-Gonzalez, N.; Ortega, E.; Lienenklaus, S.; Kalinke, U.; Ludwig, S.; Engel, D. R.; Rosenbauer, F.; Monaco, C.; Dersch, P.; Kibler, A.; Cerutti, A.; Chavakis, T.; Benedito, R.; Hidalgo, A.; Jablonska, J.; Palomino-Segura, M.; Soehnlein, O.

2026 Sci Immunol

SARS-CoV-2 Peptide Fragments Selectively Dysregulate Specific Immune Cell Populations via Gaussian Curvature Targeting

Zhang, Y.; Silvestre-Roig, C.; Fu, H.; Alimohamadi, H.; Mandal, T.; Chen, J. W.; Luo, E. W.-C.; Anda, J. D.; Linard Matos, A. L.; Richter, M.; Mennella, A.; Lee, H.; Chan, L. C.; Wang, Y.; Wang, N.; Wang, H.; Wang, X.; Lee, C. K.; Ghosh, S.; Matsui, T.; Weiss, T. M.; Guo, T.; Zhang, M.; Li, D.; Wolfgang, M. C.; Hagan, R. S.; Li, M. M. H.; Gunzer, M.; Sickmann, A.; Frasca, L.; Yeaman, M. R.; Lande, R.; Cui, Q.; Soehnlein, O.; Wong, G. C. L.

2026 Proc Natl Acad Sci

The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke Severity

Strecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J.

2025 bioRxiv

Neutrophil Progenitor Mobilization Is a Distinct Feature of STEMI and Predicts Survival

Richter, M.; Von Göwels*, J.; Fähndrich*, M.; Fernandez*, C. L.; Grohn*, K.; Schwarz, D.; Lang, A.; Polzin, A.; Farinola, L.; Gosh, S.; Groba, S. R.; Heming, J.-N.; Aleth, H.; Rübsamen, N.; Radecke, T.; Rosenbauer, F.; Sickmann, A.; Karch, A.; Zarbock, A.; Minnerup, J.; Sindermann, J.; Bender, A.; Rossaint, J.; Ormanns, S.; Gunzer, M.; Reinecke, H.; Makowski, L.; Jung, C.; Silvestre-Roig, C.; Kelm, M.; Gerdes, N.; Chevre, R.; Lange, S.; Soehnlein, O.

2025 Research Square

From complexity to consensus: A roadmap for neutrophil classification

Ng, L. G.; Ballesteros, I.; Cassatella, M. A.; Egeblad, M.; Fridlender, Z. G.; Gabrilovich, D.; Gao, Q.; Granot, Z.; Grieshaber-Bouyer, R.; Grimes, H. L.; Hedrick, C. C.; Hidalgo, A.; Kaplan, M. J.; Kubes, P.; Ling, G. S.; Lu, L.; Luo, H. R.; Mayadas, T. N.; Moutsopoulos, N. M.; Ng, M.; Nigrovic, P. A.; Ostuni, R.; Pittet, M. J.; Quail, D. F.; Silvestre-Roig, C.; Soehnlein, O.; Udalova, I. A.; Xue, R.; Zhang, N.; Kwok, I.

2025 Immunity

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

Gatsiou, A.; Tual-Chalot, S.; Napoli, M.; Ortega-Gomez, A.; Regen, T.; Badolia, R.; Cesarini, V.; Garcia-Gonzalez, C.; Chevre, R.; Ciliberti, G.; Silvestre-Roig, C.; Martini, M.; Hoffmann, J.; Hamouche, R.; Visker, J. R.; Diakos, N.; Wietelmann, A.; Silvestris, D. A.; Georgiopoulos, G.; Moshfegh, A.; Schneider, A.; Chen, W.; Guenther, S.; Backs, J.; Kwak, S.; Selzman, C. H.; Stamatelopoulos, K.; Rose-John, S.; Trautwein, C.; Spyridopoulos, I.; Braun, T.; Waisman, A.; Gallo, A.; Drakos, S. G.; Dimmeler, S.; Sperandio, M.; Soehnlein, O.; Stellos, K.

2023 Immunity