Host-pathogen interactions in neutrophils
In this proposal, we will decipher the role of coronin 1A (CORO1A) and its interacting partner secretory carrier-associated membrane protein 3 (SCAMP3) for pathogen escape strategies in neutrophils upon infection with Helicobacter pylori and Mycobacterium species. As these pathogens recruit CORO1A to their intracellular niche, we will study how CORO1A and SCAMP3 may be hijacked by these pathogens to circumvent host defence. The identification of these molecular mechanisms may improve our understanding of neutrophil-dependent pathogen escape strategies and can lead to the development of novel therapeutic concepts.
Team
Publications
Mutations in VPS18 Lead to a Neutrophil Maturation Defect Associated with Disturbed Vesicle HomeostasisGao, J.; Bader, A.; Linder, M. I.; Cheng, J.; Richter, M.; Da Costa, R.; Zehrer, A.; Mitt, K.; Popper, B.; Meissner, F.; Wei, X.; De Vega Gómez, E.; Tatematsu, M.; Rohlfs, M.; Frenz-Wiessner, S.; Kiziltug, M.; Somekh, I.; Yacobovich, J.; Steinberg-Shemer, O.; Somech, R.; Soehnlein, O.; Schmid, B.; Klein, C.; Walzog, B.; Maier-Begandt, D.
2026 Cell Death Dis
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The Nuclear Receptor NR4A1 Serves as a Neutrophil-Intrinsic Regulator Mitigating Stroke SeverityStrecker, J.-K.; Schmidt, Y.; Liebmann, M.; Walter, C.; Roth, S.; Aleth, H.; Börsch, A.-L.; Schmidt-Pogoda, A.; Beuker, C.; Yusuf, A. M.; Revenstorff, J.; Osei-Sarpong, C.; Krafft, L.; Schwarze, A.-S.; Heming, M.; Richter, M.; Kuhlmann, T.; Hucke, S.; Heming, J.-N.; Hansen, U.; Hagemann, N.; Bader, A.; Gao, J.; Walzog, B.; Maier-Begandt, D.; Chevre, R.; Hanschmann, E.-M.; Lücke, M.; Sommer, C.; Hermann, D. M.; Roth, J.; Thomas, C.; Meyer Zu Hörste, G.; Gunzer, M.; Vogl, T.; Zarbock, A.; Rosenbauer, F.; Silvestre-Roig, C.; Söhnlein, O.; Klotz, L.; Minnerup, J.
2025 bioRxiv
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Sex Differences in Neutrophil BiologyRichter, M.; Maier-Begandt, D.; Jablonska, J.; Silvestre-Roig, C.
2025 J Leukoc Biol
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SCAMP3 Is Essential for Proper Formation and Function of Neutrophil GranulesBader, A.; Gao, J.; Reiter, N.; Siemes, D.; Zehrer, A.; Wei, X.; Hepper, I.; de Vega Gómez, E.; Schmid, B.; Forné, I.; Engel, D. R.; Walzog, B.; Maier-Begandt, D.
2025 J Leukoc Biol
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Cytosolic S100A8/A9 Promotes Ca2+ Supply at LFA-1 Adhesion Clusters during Neutrophil RecruitmentNapoli, M.; Immler, R.; Rohwedder, I.; Lupperger, V.; Pfabe, J.; Gonzalez Pisfil, M.; Yevtushenko, A.; Vogl, T.; Roth, J.; Salvermoser, M.; Dietzel, S.; Slak Rupnik, M.; Marr, C.; Walzog, B.; Sperandio, M.; Pruenster, M.
2024 Elife
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Novel Multiphoton Intravital Imaging Enables Real-Time Study of Helicobacter Pylori Interaction with Neutrophils and Macrophages in the Mouse StomachIshikawa-Ankerhold, H.; Busch, B.; Bader, A.; Maier-Begandt, D.; Dionisio, F.; Namineni, S.; Vladymyrov, M.; Harrison, U.; van den Heuvel, D.; Tomas, L.; Walzog, B.; Massberg, S.; Schulz, C.; Haas, R.
2024 PLoS Pathog
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Neutrophils - Biology and DiversityMaier-Begandt, D.; Alonso-Gonzalez, N.; Klotz, L.; Erpenbeck, L.; Jablonska, J.; Immler, R.; Hasenberg, A.; Mueller, T. T.; Herrero-Cervera, A.; Aranda-Pardos, I.; Flora, K.; Zarbock, A.; Brandau, S.; Schulz, C.; Soehnlein, O.; Steiger, S.; the TRR332 consortium.
2023 Nephrol Dial Transplant
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A20 and the Noncanonical NF-κB Pathway Are Key Regulators of Neutrophil Recruitment during Fetal OntogenyRohwedder, I.; Wackerbarth, L. M.; Heinig, K.; Ballweg, A.; Altstätter, J.; Ripphahn, M.; Nussbaum, C.; Salvermoser, M.; Bierschenk, S.; Straub, T.; Gunzer, M.; Schmidt-Supprian, M.; Kolben, T.; Schulz, C.; Ma, A.; Walzog, B.; Heinig, M.; Sperandio, M.
2023 JCI Insight
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Human Genetic Defects in SRP19 and SRPRA Cause Severe Congenital Neutropenia with Distinctive Proteome ChangesLinder, M. I.; Mizoguchi, Y.; Hesse, S.; Csaba, G.; Tatematsu, M.; Łyszkiewicz, M.; Zietara, N.; Jeske, T.; Hastreiter, M.; Rohlfs, M.; Liu, Y.; Grabowski, P.; Ahomaa, K.; Maier-Begandt, D.; Schwestka, M.; Pazhakh, V.; Isiaku, A.; Briones Miranda, B.; Blombery, P.; Saito, M. K.; Rusha, E.; Alizadeh, Z.; Pourpak, Z.; Kobayashi, M.; Rezaei, N.; Unal, E.; Hauck, F.; Drukker, M.; Walzog, B.; Rappsilber, J.; Zimmer, R.; Lieschke, G. J.; Klein, C.
2023 Blood
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